484598-36-9

Basic information

• Product Name: ProTx II
• Synonyms: ProTx II;ProToxin-II;PT-II
• CAS NO: 484598-36-9
• Molecular Formula: C168H250N46O41S8
• Molecular Weight: 3826.5862
• Mol File: 484598-36-9.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C
• CAS DataBase Reference: ProTx II(CAS DataBase Reference)
• NIST Chemistry Reference: ProTx II(484598-36-9)
• EPA Substance Registry System: ProTx II(484598-36-9)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• Hazardous Substances Data: 484598-36-9(Hazardous Substances Data)

Usage

Uses

ProTx-II is a potent, selective Nav1.7 blocker. Voltage-gated sodium channels (Nav) are responsible for transducing extracellular signals into action potentials in excitable cells. The Nav1 family consists of nine sub-types for which selective tools are highly valued. Discovery of subtype-selective tools has been challenging due to conservation of putative binding sites. Nav1.7 is expressed in sensory neurons and is critical for pain processing. ProTx-II, isolated from the tarantula Thrixopelma pruriens, is a potent blocker of Nav1 channels. Although ProTx-II blocks several members of this channel family, it has >100-fold selectivity for Nav1.7. ProTx-II is active in an in vitro model of pain processing. ProTx-II binds to a previously unknown site on the channel, conferring selectivity and increasing its value as a research tool. It blocks Nav1.7 by decreasing conductance and shifting the activation potential in the positive direction, resulting in an overall decrease in excitability.