484598-36-9

Basic information

• Product Name: ProTx II
• Synonyms: ProTx II;ProToxin-II;PT-II
• CAS NO: 484598-36-9
• Molecular Formula: C168H250N46O41S8
• Molecular Weight: 3826.5862
• Mol File: 484598-36-9.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C
• CAS DataBase Reference: ProTx II(CAS DataBase Reference)
• NIST Chemistry Reference: ProTx II(484598-36-9)
• EPA Substance Registry System: ProTx II(484598-36-9)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• Hazardous Substances Data: 484598-36-9(Hazardous Substances Data)

Usage

Description

ProTx II, isolated from the tarantula Thrixopelma pruriens, is a potent and selective blocker of the voltage-gated sodium channel Nav1.7. It plays a crucial role in pain processing and has a high selectivity for Nav1.7 over other members of the Nav1 family. ProTx II is valuable as a research tool and has potential applications in various fields due to its unique binding site and mechanism of action.

Uses

Used in Pain Management:
ProTx II is used as a pain management agent for targeting the Nav1.7 channel, which is critical for pain processing in sensory neurons. By blocking Nav1.7, ProTx II can effectively reduce pain signals and provide relief for various types of pain.
Used in Neuroscience Research:
ProTx II is used as a research tool for studying the function and regulation of voltage-gated sodium channels, particularly Nav1.7. Its high selectivity and unique binding site make it an invaluable asset for understanding the role of these channels in various physiological processes and for developing targeted therapies.
Used in Drug Development:
ProTx II is used as a lead compound in the development of new drugs targeting Nav1.7 for the treatment of pain and other related conditions. Its selectivity and mechanism of action can guide the design of more potent and selective therapeutic agents.
Used in Ion Channel Research:
ProTx II is used as a selective Nav1.7 blocker in the study of ion channel biology, helping researchers understand the structure, function, and regulation of these important proteins. This knowledge can contribute to the development of novel therapeutic strategies for various diseases and conditions.