484648-95-5

Basic information

• Product Name: Carbamic acid, [(1S)-1-[[[2-(2-chlorophenyl)ethyl]amino]carbonyl]-3,3-difluoropropyl]-, phenylmethyl ester
• CAS NO: 484648-95-5
• Molecular Formula: C20H21ClF2N2O3
• Molecular Weight: 410.848
• Mol File: 484648-95-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(1S)-1-[[[2-(2-chlorophenyl)ethyl]amino]carbonyl]-3,3-difluoropropyl]-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1S)-1-[[[2-(2-chlorophenyl)ethyl]amino]carbonyl]-3,3-difluoropropyl]-, phenylmethyl ester(484648-95-5)
• EPA Substance Registry System: Carbamic acid, [(1S)-1-[[[2-(2-chlorophenyl)ethyl]amino]carbonyl]-3,3-difluoropropyl]-, phenylmethyl ester(484648-95-5)

Safety Data

• Hazardous Substances Data: 484648-95-5(Hazardous Substances Data)

Upstream product

• 13078-80-3 2-(2-chlorophenyl)ethanamine 
• 467438-39-7 (2S)-2-{[(benzyloxy)carbonyl]amino}-4,4-difluorobutanoic acid 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 

Relevant articles and documents

Phenethyl amides as novel noncovalent inhibitors of hepatitis C virus NS3/4A protease: Discovery, initial SAR, and molecular modeling

The discovery of novel, reversible and competitive tripeptide inhibitors of the Hepatitis C virus NS3/4A serine protease is described. These inhibitors are characterized by the presence of a C-terminal phenethyl amide group, which extends into the prime side of the enzyme. Initial SAR together with molecular modeling and data from site-directed mutagenesis suggest an interaction of the phenethyl amide group with Lys-136.