484670-64-6

Basic information

• Product Name: clarithromycin dibenzoate
• Synonyms: clarithromycin dibenzoate
• CAS NO: 484670-64-6
• Molecular Weight: 956.181
• Mol File: 484670-64-6.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: clarithromycin dibenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: clarithromycin dibenzoate(484670-64-6)
• EPA Substance Registry System: clarithromycin dibenzoate(484670-64-6)

Safety Data

• Hazardous Substances Data: 484670-64-6(Hazardous Substances Data)

Upstream product

• 81103-11-9 clarithromycin 
• 93-97-0 benzoic acid anhydride 
• 134930-93-1 erythromycin A 9(E)-O-(1-methoxy-1-methylethyl)oxime 
• 13127-18-9 (9-E)-deoxo-9-hydroximinoerythromycin A 
• 129288-90-0 erythromycin A 9-O-(1-methoxy-1-methylethyl)oxime 
• 114-07-8 erythromycin 
• 1349852-75-0 2',4''-dibenzoyl-O-(2-methoxy-2-propyl)erythromycin A 9-oxime 
• 74-88-4 methyl iodide 

Downstream Products

• 484670-61-3 C₅₂H₇₉NO₁₅ 
• 484670-62-4 C₅₅H₈₁NO₁₄ 
• 484671-59-2 Benzoic acid (2S,3R,4S,6R)-4-dimethylamino-2-((E)-(3R,5R,6R,7R,9R,13S,14R)-14-ethyl-13-formyl-13-hydroxy-7-methoxy-3,5,7,9,11-pentamethyl-2,4,10-trioxo-oxacyclotetradec-11-en-6-yloxy)-6-methyl-tetrahydro-pyran-3-yl ester 
• 484671-60-5 Benzoic acid (2S,3R,4S,6R)-4-dimethylamino-2-((E)-(3R,5R,6R,7R,9R,13S,14R)-14-ethyl-13-hydroxy-7-methoxy-3,5,7,9,11-pentamethyl-2,4,10-trioxo-13-vinyl-oxacyclotetradec-11-en-6-yloxy)-6-methyl-tetrahydro-pyran-3-yl ester 
• 484671-58-1 Benzoic acid (2S,3R,4S,6R)-4-dimethylamino-2-((E)-(3R,4S,5S,6R,7R,9R,13R,14R)-14-ethyl-4,13-dihydroxy-13-hydroxymethyl-7-methoxy-3,5,7,9,11-pentamethyl-2,10-dioxo-oxacyclotetradec-11-en-6-yloxy)-6-methyl-tetrahydro-pyran-3-yl ester 
• 484671-61-6 Imidazole-1-carboxylic acid (E)-(2R,3S,7R,9R,10R,11R,13R)-10-((2S,3R,4S,6R)-3-benzoyloxy-4-dimethylamino-6-methyl-tetrahydro-pyran-2-yloxy)-2-ethyl-9-methoxy-5,7,9,11,13-pentamethyl-6,12,14-trioxo-3-vinyl-oxacyclotetradec-4-en-3-yl ester 
• 484673-82-7 C₅₁H₆₉N₅O₁₁ 
• 484670-65-7 C₅₂H₇₇NO₁₄ 

Relevant articles and documents

A preparation of a macrocyclic lactone method

The invention relates to a new preparation method of macrolides, belonging to the field of medicinal chemistry. The invention further relates to a preparation method of Solithromycin. The new preparation method comprises the following step of carrying out 7-th position saccharide ring removal, hydroxyl oxidation and reductive amination with a side chain to obtain an important intermediate (5) having a formula shown in the specification. The preparation method of Solithromycin, disclosed by the invention, has the advantages of few side reactions, operation simpleness and convenience, high yield and high suitability for industrial production. The structure of the intermediate (5) is as shown in the specification.

PROCESSES FOR PREPARING MACROLIDES AND KETOLIDES AND INTERMEDIATES THEREFOR

The invention described herein pertains to processes for the preparation of macrolide antibacterial agents. In particular, the invention pertains to processes for preparing macrolides and ketolides from erythromycin A.

Synthesis and antibacterial activity of C-12 pyrazolinyl spiro ketolides

A series of C-12 pyrazolinyl spiro ketolide derivatives were designed and synthesized. The C-12 modifications involved replacing the natural C-12 methyl group in clarithromycin core with different pyrazolinyl spiros via chemical synthesis. Potential anti-