484684-79-9Relevant academic research and scientific papers
Synthesis of 2-azetidinones substituted coumarin derivatives
Mashelkar, Uday C.,Jha, Mukesh S.,Mashelkar, Beena U.
, p. 1339 - 1344 (2012)
α-Naphthol was converted into 4-methyl-2H-benzo[h]chromen-2-one by reacting with ethyl acetoacetate in the presence of bismuth trichloride. The product was oxidized to 2-oxo-2H-benzo[h]chromene-4-carbaldehyde and then condensed with aromatic primary amines to give Schiff bases 3a-d. These Schiff bases were then reacted with acid chlorides in the presence of a base in toluene to give 1,3,4-substituted 2-azetidinones.
