485-08-5Relevant academic research and scientific papers
A reinvestigated mechanism of ribosylation of adenine under silylating conditions
Framski, Grzegorz,Gdaniec, Zofia,Gdaniec, Maria,Boryski, Jerzy
, p. 10123 - 10129 (2007/10/03)
The mechanism of chemical synthesis of adenosine has been reinvestigated. Depending on the reaction conditions and the presence of N6-protecting groups, ribosylation of adenine proceeds via different kinetic products: 3-riboadenine in strongly acidic media, 7-ribosylated derivative in the silyl method, and 1-(β-d-ribofuranosyl)adenine when applying N6-acyladenine and silylating conditions.
1,1,1,3,3,3-Hexafluoro-2-propanol for the Removal of the 4,4'-Dimethoxytrityl Protecting Group from the 5'-Hydroxyl of Acid-Sensitive Nucleosides and Nucleotides
Leonard, Nelson J.,Neelima
, p. 7833 - 7836 (2007/10/02)
1,1,1,3,3,3-Hexafluoro-2-propanol is introduced as a suitable reagent and solvent for the detritylation of 5'-O-(4,4'-dimethoxytrityl)-nucleosides and -deoxy- nucleosides, especially those that are susceptible to N-glycosyl cleavage under more strongly acidic conditions.
