485337-88-0Relevant academic research and scientific papers
Synthetic approach and functionalization of novel 4-anilinoquinolino-quinazoline heterocyclic scaffolds
Derabli, Chamseddine,Boulcina, Raouf,Kirsch, Gilbert,Debache, Abdelmadjid
, p. 351 - 358 (2017)
An efficient and high yielding protocol is reported for the synthesis of new class of 4-anilinoquinolino-quinazoline hybrids. The target compounds were prepared first by the reaction of 2-aminobenzamide with 2-chloroquinoline-3-carbaldehydes. After oxidation and chlorination, the key 2-quinolyl-4-chloroquinazolines were converted to the corresponding 2-(2-arylaminoquinolyl)-4-arylaminoquinazolines and N-heteroaryl-2-(2-(heteroarylamino)quinolin-3-yl)quinazolin-4-amines.
Sulfonic acid functionalized Wang resin (Wang-OSO3H) as polymeric acidic catalyst for the eco-friendly synthesis of 2,3-dihydroquinazolin-4(1H)-ones In memory of Dr. K. Anji Reddy, the founder of Dr. Reddy's Laboratories Ltd DRL Communication no.: IPDO IPM-00443
Dhanunjaya Rao,Vykunteswararao,Bhaskarkumar,Jogdand, Nivrutti R.,Kalita, Dipak,Lilakar, Jaydeep Kumar D.,Siddaiah, Vidavalur,Douglas Sanasi, Paul,Raghunadh, Akula
, p. 4714 - 4717 (2015/08/06)
Abstract An efficient and green approach has been developed for the synthesis of 2-substituted 2,3-dihydroquinazolin-4(1H)-ones directly from corresponding substituted aromatic and aliphatic aldehyde and anthranilamide using recyclable polymer supported sulfonic acid catalyst under aqueous conditions. Environmental acceptability, operational simplicity, low cost, excellent functional group compatibility, and high yields are the important features of this protocol.
An efficient one pot-three component cyclocondensation in the synthesis of 2-(2-chloroquinolin-3-yl)-2,3-dihydroquinazolin-4(1H)-ones: Potential antitumor agents
Roopan, Selvaraj Mohana,Nawaz Khan,Jin, Jong Sung,Senthil Kumar
experimental part, p. 919 - 927 (2012/05/20)
Montmorillonite K10 efficiently catalyzed a one pot-three component cyclocondensation of isatoic anhydride, NH4OAc and aromatic/heteroaromatic aldehydes under ambient conditions to produce the corresponding 2-substituted-2,3-dihydroquinazolin-4(1H)-ones in good yields. The 2-(2-chloroquinolin-3-yl)-2,3-dihydroquinazolin-4(1H)-ones 3a-d were screened for their antitumor activity against Ehrlich Ascites Carcinoma tumor cells
