485389-97-7Relevant academic research and scientific papers
Regio- and stereochemistry of inter- and intramolecular titanium-mediated coupling of imides and mono-substituted olefins
Kim, Se-Ho,Park, Yongyoub,Choo, Hyunah,Cha, Jin Kun
, p. 6657 - 6660 (2002)
The intramolecular titanium-mediated coupling reaction of α-substituted succinimides and mono-substituted olefins took place with complete regiocontrol, but without diastereoselectivity. The corresponding intermolecular coupling exhibited lack of regio- and diastereocontrol. Also included were stereochemical studies of catalytic hydrogenation and NaBH3CN reduction of the cyclization products.
A versatile approach to cis-5-substituted 4-hydroxy-2-pyrrolidinones: asymmetric synthesis of angiogenesis inhibitor streptopyrrolidine
Xiang, Shao-Hua,Yuan, Hong-Qiu,Huang, Pei-Qiang
scheme or table, p. 2021 - 2026 (2010/02/28)
A concise, flexible, and highly diastereoselective approach to cis-5-alkyl-4-hydroxy-2-pyrrolidinones 1 is described. The key step is an ammonium acetate-assisted catalytic hydrogenation of the enamides 9, derived in two steps from malimides 6a,b as we ha
A versatile approach to protected (4S,5R)-4-hydroxy-5-(α- hydroxyalkyl)-2-pyrrolidinones
Zhou, Xiang,Huang, Pei-Qiang
, p. 1235 - 1239 (2007/10/03)
Starting from (S)-N,O-dibenzylmalimide (7), a versatile four-step approach to (4S,5R)-N-benzyl-4-benzyloxy-5-(α-hydroxyalkyl)-2-pyrrolidinones 9 is reported. The method consists of Grignard reagent addition, p-toluenesulfonic acid monohydrate-mediated deh
