485392-99-2Relevant academic research and scientific papers
Scaffold-hopping with zwitterionic CCR3 antagonists: Identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092
Barton, Patrick,Caffrey, Moya V.,Linannen, Tero,Luckhurst, Christopher A.,Mochel, Tobias,Perry, Matthew W. D.,Springthorpe, Brian,Stein, Linda,Bahl, Ash,Bowers, Keith,Gilmour, Peter,Hawley, Shaun,Denton, Rebecca,Riley, Robert J.,Roe, Emma,Webborn, Peter
supporting information, p. 6694 - 6699,6 (2012/12/12)
The discovery and optimisation of a series of zwitterionic CCR3 antagonists is described. Optimisation of the structure led to AZ12436092, a compound with excellent selectivity over activity at hERG and outstanding pharmacokinetics in preclinical species.
NOVEL PIPERIDINE DERIVATIVES FOR USE IN THE TREATMENT OF CHEMOKINE MEDIATED DISEASE STATES
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Page 20, (2010/02/06)
The present invention provides a compound of a formula (I): wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a chemokine (such as CCR3) or H1 mediated disease state.
