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1-acetamidocyclopentane-1-carboxylic acid, also known as Cyclopentylglycine, is a unique non-proteinogenic amino acid characterized by a cyclopentane ring with a carboxylic acid group and an acetamide group. This chemical compound does not participate in protein synthesis during translation but has demonstrated significant pharmacological potential, particularly in the inhibition of TDP-43 aggregation, a process linked to neurodegenerative conditions such as amyotrophic lateral sclerosis and frontotemporal dementia. Furthermore, its utility in medicinal chemistry as a component in the synthesis of peptide-based drugs underscores its versatility and promise in research and development.

4854-46-0

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4854-46-0 Usage

Uses

Used in Pharmaceutical Research:
1-acetamidocyclopentane-1-carboxylic acid serves as a key building block in the synthesis of peptide-based pharmaceuticals, leveraging its unique structural properties to enhance the development of novel therapeutic agents.
Used in Neurodegenerative Disease Treatment:
As an inhibitor of TDP-43 aggregation, 1-acetamidocyclopentane-1-carboxylic acid is utilized as a potential therapeutic agent for the treatment of neurodegenerative diseases, specifically targeting conditions like amyotrophic lateral sclerosis and frontotemporal dementia, where the aggregation of TDP-43 is implicated in disease progression.
Used in Medicinal Chemistry:
1-acetamidocyclopentane-1-carboxylic acid is employed as a versatile compound in medicinal chemistry, contributing to the design and synthesis of innovative peptide-based drugs, thereby expanding the scope of available treatments for various medical conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 4854-46-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,8,5 and 4 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 4854-46:
(6*4)+(5*8)+(4*5)+(3*4)+(2*4)+(1*6)=110
110 % 10 = 0
So 4854-46-0 is a valid CAS Registry Number.
InChI:InChI=1/C8H13NO3/c1-6(10)9-8(7(11)12)4-2-3-5-8/h2-5H2,1H3,(H,9,10)(H,11,12)

4854-46-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-acetamidocyclopentane-1-carboxylic acid

1.2 Other means of identification

Product number -
Other names 1-Acetamidocyclopentanecarboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
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More Details:4854-46-0 SDS

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