485402-64-0 Usage
Uses
Used in Pharmaceutical Industry:
Benzenamine, 3-cyclopropyl-, is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical industry, Benzenamine, 3-cyclopropyl-, serves as a precursor in the production of agrochemicals, contributing to the development of effective pesticides and other agricultural products.
Used in Dye and Pigment Industry:
Benzenamine, 3-cyclopropyl-, is utilized in the synthesis of dyes and pigments, providing a wide range of colors and properties for various applications, including textiles, plastics, and printing inks.
Used in Rubber Chemical Industry:
Benzenamine, 3-cyclopropylis also employed in the rubber chemical industry, where it contributes to the production of various rubber chemicals that enhance the performance and durability of rubber products.
Used in Research and Development:
Benzenamine, 3-cyclopropyl-, is used in research and development for exploring its potential applications and properties, leading to the discovery of new compounds and technologies.
Check Digit Verification of cas no
The CAS Registry Mumber 485402-64-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,8,5,4,0 and 2 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 485402-64:
(8*4)+(7*8)+(6*5)+(5*4)+(4*0)+(3*2)+(2*6)+(1*4)=160
160 % 10 = 0
So 485402-64-0 is a valid CAS Registry Number.
485402-64-0Relevant academic research and scientific papers
Discovery, optimization and evaluation of 1-(indolin-1-yl)ethan-1-ones as novel selective TRIM24/BRPF1 bromodomain inhibitors
Xiang, Qiuping,Luo, Guolong,Zhang, Cheng,Hu, Qingqing,Wang, Chao,Wu, Tianbang,Xu, Hongrui,Hu, Jiankang,Zhuang, Xiaoxi,Zhang, Maofeng,Wu, Shuang,Xu, Jinxin,Zhang, Yan,Liu, Jinsong,Xu, Yong
, (2022/04/07)
TRIM24 (tripartite motif-containing protein 24) and BRPF1 (bromodomain and PHD finger containing protein 1) are epigenetics “readers” and potential therapeutic targets for cancer and other diseases. Here we describe the structure-guided design of 1-(indolin-1-yl)ethan-1-ones as novel TRIM24/BRPF1 bromodomain inhibitors. The representative compound 20l (Y08624) is a new TRIM24/BRPF1 dual inhibitor, with IC50 values of 0.98 and 1.16 μM, respectively. Cellular activity of 20l was validated by viability assay in prostate cancer (PC) cell lines. In PC xenograft models, 20l suppressed tumor growth (50 mg/kg/day, TGI = 53%) without exhibiting noticeable toxicity. Compound 20l represents a versatile starting point for the development of more potent TRIM24/BRPF1 inhibitors.
