485402-64-0

Basic information

• Product Name: Benzenamine, 3-cyclopropyl-
• Synonyms: Benzenamine, 3-cyclopropyl-;3-cyclopropylBenzenamine
• CAS NO: 485402-64-0
• Molecular Formula: C9H11N
• Molecular Weight: 133.19034
• Mol File: 485402-64-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 255.9±19.0 °C(Predicted)
• Appearance: /
• Density: 1.112±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 4.63±0.10(Predicted)
• CAS DataBase Reference: Benzenamine, 3-cyclopropyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 3-cyclopropyl-(485402-64-0)
• EPA Substance Registry System: Benzenamine, 3-cyclopropyl-(485402-64-0)

Safety Data

• Hazardous Substances Data: 485402-64-0(Hazardous Substances Data)

Usage

General Description

Benzenamine, 3-cyclopropyl-, also known as m-Cyclopropylaniline, is a chemical compound with the molecular formula C9H11N. It is a derivative of aniline, with a cyclopropyl group attached to the 3-position of the benzene ring. It is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. This chemical is also known for its use in the production of dyes, pigments, and rubber chemicals. Benzenamine, 3-cyclopropyl-, is considered to be a hazardous substance and should be handled with caution due to its potential health and environmental effects.

Upstream product

• 585-79-5 m-nitrobromobenzene 

Relevant articles and documents

Discovery, optimization and evaluation of 1-(indolin-1-yl)ethan-1-ones as novel selective TRIM24/BRPF1 bromodomain inhibitors

TRIM24 (tripartite motif-containing protein 24) and BRPF1 (bromodomain and PHD finger containing protein 1) are epigenetics “readers” and potential therapeutic targets for cancer and other diseases. Here we describe the structure-guided design of 1-(indolin-1-yl)ethan-1-ones as novel TRIM24/BRPF1 bromodomain inhibitors. The representative compound 20l (Y08624) is a new TRIM24/BRPF1 dual inhibitor, with IC50 values of 0.98 and 1.16 μM, respectively. Cellular activity of 20l was validated by viability assay in prostate cancer (PC) cell lines. In PC xenograft models, 20l suppressed tumor growth (50 mg/kg/day, TGI = 53%) without exhibiting noticeable toxicity. Compound 20l represents a versatile starting point for the development of more potent TRIM24/BRPF1 inhibitors.