485404-41-9

Basic information

• Product Name: Imidazo[1,2-a]pyrimidin-5(8H)-one, 8-[(2-fluorophenyl)methyl]-2-(4-methoxyphenyl)-7-methyl-6-(3,4,5-trimeth oxyphenyl)-
• CAS NO: 485404-41-9
• Molecular Formula: C30H28FN3O5
• Molecular Weight: 529.568
• Mol File: 485404-41-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Imidazo[1,2-a]pyrimidin-5(8H)-one, 8-[(2-fluorophenyl)methyl]-2-(4-methoxyphenyl)-7-methyl-6-(3,4,5-trimeth oxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Imidazo[1,2-a]pyrimidin-5(8H)-one, 8-[(2-fluorophenyl)methyl]-2-(4-methoxyphenyl)-7-methyl-6-(3,4,5-trimeth oxyphenyl)-(485404-41-9)
• EPA Substance Registry System: Imidazo[1,2-a]pyrimidin-5(8H)-one, 8-[(2-fluorophenyl)methyl]-2-(4-methoxyphenyl)-7-methyl-6-(3,4,5-trimeth oxyphenyl)-(485404-41-9)

Safety Data

• Hazardous Substances Data: 485404-41-9(Hazardous Substances Data)

Upstream product

• 446-48-0 o-fluorobenzyl bromide 
• 485404-31-7 2-(4-methoxy-phenyl)-7-methyl-6-(3,4,5-trimethoxy-phenyl)-imidazo[1,2-a]pyrimidin-5-ol 
• 182163-96-8 3,4,5-trimethoxyphenylboronic Acid 
• 6307-35-3 2-amino-5-bromo-4-hydroxy-6-methylpyrimidine 
• 14247-78-0 8H-imidazolo[1,2-α]pyrimid-5-one 
• 485404-36-2 6-bromo-8-(2-fluoro-benzyl)-2-(4-methoxy-phenyl)-7-methyl-8H-imidazo[1,2-a]pyrimidin-5-one 

Relevant articles and documents

Design, synthesis and structure-activity relationships of novel imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists

SAR studies of lead GnRH receptor antagonists 2a and 2b reported earlier resulted in the discovery of compound 10b which showed much higher potency (Ki=4.6 nM, compared with 2b, Ki=230 nM) in which the 7-position of the imidazolo[1,2-a]pyrimidone core was substituted with a methyl group, and the ester at the 6-position was replaced by the 3-methoxyphenyl group.