485404-58-8 Usage
Uses
Used in Chemical Research and Development:
Benzeneethanamine, 2-fluoro-N-methyl(9CI) is used as a research compound for studying its chemical properties and potential reactions with other substances. Its unique structure with a fluorine atom and a methyl group may offer insights into the development of new chemical processes or the synthesis of novel compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Benzeneethanamine, 2-fluoro-N-methyl(9CI) may be employed as an intermediate in the synthesis of various drug molecules. The presence of the fluorine atom can influence the pharmacokinetics and pharmacodynamics of the final drug product, potentially enhancing its efficacy, selectivity, or metabolic stability.
Used in Industrial Applications:
Benzeneethanamine, 2-fluoro-N-methyl(9CI) may also find use in specific industrial applications, such as the production of specialty chemicals, materials, or coatings. Its unique chemical properties could contribute to the development of innovative products with improved performance characteristics.
Check Digit Verification of cas no
The CAS Registry Mumber 485404-58-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,8,5,4,0 and 4 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 485404-58:
(8*4)+(7*8)+(6*5)+(5*4)+(4*0)+(3*4)+(2*5)+(1*8)=168
168 % 10 = 8
So 485404-58-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H12FN/c1-11-7-6-8-4-2-3-5-9(8)10/h2-5,11H,6-7H2,1H3
485404-58-8Relevant academic research and scientific papers
Lewin, Anita H.,Navarro, Hernan A.,Wayne Mascarella
, p. 7415 - 7423 (2008)
A cell line in which RD-HGA16 cells were stably transfected with the hTAAR 1 receptor was created and utilized to carry out a systematic evaluation of a series of β-phenethylamines. Fair agreement was observed with data obtained for aryl and ethylene chain substituted analogs in an AV12-664 cell line in which hemagglutinin-tagged hTAAR 1 was stably co-expressed with rat Gαs. Analogs with multiple substituents as well as analogs with bulky groups were found to be partial agonists. Analogs in which the primary amino group was converted to a secondary or a tertiary amino group by N-methylation were also partial agonists. Comparative Molecular Field Analysis (CoMFA) using the potency data yielded a regression coefficient r2 of 0.824. The steric field contribution to the model was 61% with the balance (39%) contributed by the electrostatic field. The collective results suggest that increasing steric bulk both at the amino nitrogen, particularly by N-dimethylation, and at the 4-position of the aromatic ring leads to low efficacy ligands.
