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Dimethyl-carbamic acid 3-methyl-4-nitro-phenyl ester, also known as aldicarb, is a synthetic organophosphorus compound primarily used as an insecticide. It is a white crystalline solid with the chemical formula C7H8N2O4. Aldicarb is highly toxic to both insects and mammals, acting as a potent acetylcholinesterase inhibitor, which disrupts the nervous system by preventing the breakdown of the neurotransmitter acetylcholine. This leads to an accumulation of acetylcholine, causing overstimulation and paralysis of the nervous system. Due to its high toxicity and potential for groundwater contamination, aldicarb has been banned or restricted in many countries. It is important to handle aldicarb with extreme caution and to follow proper safety protocols to minimize risks to human health and the environment.

4855-70-3

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4855-70-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4855-70-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,8,5 and 5 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 4855-70:
(6*4)+(5*8)+(4*5)+(3*5)+(2*7)+(1*0)=113
113 % 10 = 3
So 4855-70-3 is a valid CAS Registry Number.

4855-70-3Downstream Products

4855-70-3Relevant academic research and scientific papers

The serotonin 5-HT4 receptor. 2. Structure-activity studies of the indole carbazimidamide class of agonists.

Buchheit,Gamse,Giger,Hoyer,Klein,Kloeppner,Pfannkuche,Mattes

, p. 2331 - 2338 (2007/10/02)

A number of substituted indole carbazimidamides were prepared and evaluated as 5-HT4 receptor agonists by using the isolated field-stimulated guinea pig ileum preparation. Their selectivity for the 5-HT4 receptor was established by examining their affinity for other 5-HT receptors using radioligand-binding techniques. Several selective and highly potent full as well as partial agonists emerged from this study. For example, 1b,d were found to be the most potent, full 5-HT4 receptor agonist described so far (EC50 = 0.5 and 0.8 nM, respectively), being 6 and 4 times more potent than serotonin itself. On the other hand, 5b and 1h appeared as partial 5-HT4 receptor agonists in the nonstimulated guinea pig ileum preparation with potencies, evaluated against serotonin action, respectively similar (5b, Ki = 12 nM) to and 300-fold higher (1h, Ki = 0.04 nM) than serotonin.

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