485812-89-3

Basic information

• Product Name: Methanone, [6-methyl-2-(propylamino)-3-pyridinyl]phenyl-
• CAS NO: 485812-89-3
• Molecular Formula: C16H18N2O
• Molecular Weight: 254.332
• Mol File: 485812-89-3.mol

Chemical Properties

• CAS DataBase Reference: Methanone, [6-methyl-2-(propylamino)-3-pyridinyl]phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, [6-methyl-2-(propylamino)-3-pyridinyl]phenyl-(485812-89-3)
• EPA Substance Registry System: Methanone, [6-methyl-2-(propylamino)-3-pyridinyl]phenyl-(485812-89-3)

Safety Data

• Hazardous Substances Data: 485812-89-3(Hazardous Substances Data)

Upstream product

• 107-10-8 propylamine 
• 247188-13-2 3-benzoyl-6-methyl-2-pyridyl 4-methylbenzenesulfonate 
• 614-16-4 Benzoylacetonitrile 
• 36228-62-3 3-Benzoyl-6-methyl-2-oxopyridine 

Relevant articles and documents

Synthetic studies on selective type 4 phosphodiesterase (PDE 4) inhibitors. 1. Structure-activity relationships and pharmacological evaluation of 1,8-naphthyridin-2(1H)-one derivatives.

In order to develop novel and orally active phosphodiesterase (PDE) 4 inhibitors, random screening was performed using our chemical library to find YM-10335 possessing the 1,8-naphthyridin-2(1H)-one skeleton which is a completely different structure from rolipram. In this report, the syntheses and structure-activity relationships of the YM-10335 derivatives were described. Some compounds showed selective inhibitory activities for PDE 4 derived from human peripheral blood cells and no effect on the other PDE types (1, 2, 3, 5). The inhibition of the tumor necrosis factor-alpha (TNF-alpha) release in vitro and the carrageenan-induced pleurisy in rats were also described.