485828-45-3

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-chlorophenyl)-3-hydroxycyclobutane-1-carbonitrile is used as a building block for the synthesis of new drugs due to its distinctive chemical structure. Its potential lies in the ability to be a part of creating novel pharmaceutical compounds with specific therapeutic properties.
Additionally, 1-(4-chlorophenyl)-3-hydroxycyclobutane-1-carbonitrile may possess its own biological activities, which could be harnessed for therapeutic purposes. However, further research and testing are necessary to fully comprehend its potential uses and effects on human health and the environment.

Upstream product

• 917-64-6 methyl magnesium iodide 
• 96479-96-8 1-bromo-2,3-epoxypropane 
• 140-53-4 p-chlorobenzyl cyanide 
• 106-89-8 epichlorohydrin 

Downstream Products

• 186521-87-9 1-(4-Chloro-phenyl)-3-(tetrahydro-pyran-2-yloxy)-cyclobutanecarbonitrile 
• 633317-62-1 3-(4-chlorophenyl)-cis-3-cyanocyclobutyl benzoate 
• 1026046-35-4 1-[1-(4-Chloro-phenyl)-3-(tetrahydro-pyran-2-yloxy)-cyclobutyl]-3-methyl-butylamine 

Relevant academic research and scientific papers

Phenylcyclobutyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type I

3-(Phenylcyclobutyl)-1,2,4-triazoles were identified as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). These were active both in vitro and in an in vivo mouse pharmacodynamic (PD) model. Fluorine substitution of the cyclobutan

11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 INHIBITORS USEFUL FOR THE TREATMENT OF DIABETES, OBESITY AND DYSLIPIDEMIA

Compounds having Formula (I), including pharmaceutically acceptable salts, hydrates and solvates thereof, are selective inhibitors of the 11β-HSD1 enzyme. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dylsipidemia, hyperlipidemia, hypertension, Syndrome X, and other symptoms associated with NIDDM.