485831-41-2Relevant academic research and scientific papers
The synthesis of azapeptidomimetic beta-lactam molecules as potential protease inhibitors.
Malachowski, William P,Tie, Chenyang,Wang, Katherine,Broadrup, Robert L
, p. 8962 - 8969 (2007/10/03)
Synthetic methods for the construction of a novel peptidomimetic structure are reported. The structure incorporates a beta-lactam and an azapeptide in a peptide backbone with the intention of generating rationally designed substrate-based protease inhibitors. The beta-lactam is formed by subjecting serine or threonine-azapeptides to Mitsunobu reaction conditions. Importantly, the azapeptidomimetic beta-lactam structure permits extended binding inhibition and the synthetic methods to create tetrapeptidomimetic structures are described.
