485831-83-2Relevant academic research and scientific papers
Anti-infective agents
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Page/Page column 11, (2008/12/08)
The present invention relates to the use of molecules having a spacer unit, linker and recognition unit(s) for the treatment and prevention of various diseases, disorders and conditions. In particular, the present invention provides compounds useful in pr
Molecular recognition of carbohydrates with acyclic pyridine-based receptors
Mazik, Monika,Radunz, Wolfgang,Boese, Roland
, p. 7448 - 7462 (2007/10/03)
The recognition capabilities of acyclic pyridine-based receptors toward monosaccharides were evaluated. Aminopyridine receptors based on the 2,4,6-trimethyl- or 2,4,6-triethylbenzene frame show high β vs α binding selectivity in the recognition of glucopyranosides. Amidopyridine receptors, which are sterically less hindered at nitrogen, display high efficiency and an inverse selectivity. The 2-aminopyridine group has been established as a highly effective recognition group in the binding of monosaccharides. The factors influencing the binding properties of receptors 1-15, which differ in the nature and number of binding and spacer subunits used as the buildings blocks, are discussed.
High α/β-Anomer Selectivity in Molecular Recognition of Carbohydrates by Artificial Receptors
Mazik, Monika,Radunz, Wolfgang,Sicking, Willi
, p. 4579 - 4582 (2007/10/03)
(Matrix Presented) New effective, acyclic, pyridine-based receptors 1-3 show remarkable α/β binding selectivity in the recognition of monosaccharides. They are able to participate in cooperative and bidentate hydrogen bonds with sugar hydroxyls as well as
