4859-45-4

Usage

Derived from

naphthalene carboxylic acid

Structure

features a benzene ring with two carboxyl groups attached at different positions

Potential applications

pharmaceutical industry

Use in synthesis

building block for the synthesis of novel drug molecules

Current status

precise uses and properties still under investigation

Reasons for interest

unique structure and potential reactivity

Relevance

target for further research and development in organic chemistry and drug discovery

Upstream product

• 412036-98-7 2-(1-carbamoyl-[2]naphthyl)-benzoic acid 
• 2051-10-7 5,6-chrysenedione 
• 412033-93-3 2-(2-carbamoyl-phenyl)-[1]naphthoic acid 
• 218-01-9 chrysene 

Downstream Products

• 109807-77-4 methyl 2-(2-(methoxycarbonyl)phenyl)-1-naphthoate 
• 238-84-6 benzo[a]fluorene 

Relevant academic research and scientific papers

Organocatalytic aerobic oxidative cleavage of cyclic 1,2-diketones

The first organocatalytic aerobic oxidative cleavage of cyclic 1,2-diketones is reported. The reaction occurs in either aqueous or alcoholic media and is promoted by a simple N-heterocyclic carbene catalyst derived from a 1,2,4-triazolium ion. No strong oxidants are required. The application of the process in a one-pot synthesis of a cyclic anhydride is also possible. Georg Thieme Verlag Stuttgart. New York.

In situ generation of hydroperoxide by oxidation of benzhydrols to benzophenones using sodium hydride under oxygen atmosphere: Use for the oxidative cleavage of cyclic 1,2-diketones to dicarboxylic acids

A facile oxidative cleavage of cyclic 1,2-diketones 1 to dicarboxylic acids 3 with hydroperoxide generated in situ has been developed. In situ generation of hydroperoxide was effected by the oxidation of 4,4′-dichlorobenzhydrol 2f to 4,4′-dichlorobenzophenone 4f using sodium hydride under oxygen atmosphere.