4860-88-2

Usage

Uses

Used in Pharmaceutical Industry:
2-hydroxy-7-methyl-4H,5H-pyrano[4,3-b]pyran-4,5-dione is used as a potential therapeutic agent for its potential biological activities. 2-hydroxy-7-methyl-4H,5H-pyrano[4,3-b]pyran-4,5-dione is being studied for its possible applications in medicine, with the aim of developing new treatments based on its unique structure and properties.
Used in Drug Discovery and Development:
In the field of drug discovery and development, 2-hydroxy-7-methyl-4H,5H-pyrano[4,3-b]pyran-4,5-dione serves as a promising candidate for the creation of novel pharmaceuticals. Its unique structure and potential biological activities make it a valuable subject for research, with the goal of identifying and optimizing its therapeutic effects for various medical conditions.

Upstream product

• 675-10-5 4-hydroxy-6-methyl-2-pyron 
• 1663-67-8 malonoyl dichloride 
• 771-03-9 3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one 
• 29736-80-9 3,5-dioxohexanoic acid methyl ester 
• 33176-11-3 2,7-dimethyl-4H-pyrano<3,2-c>-2H-pyran-4,5-dione 

Downstream Products

• 16929-94-5 Methyl 2,4,6-trihydroxy-3-acetylbenzoate 
• 480-64-8 orsellinic acid 
• 57439-16-4 methyl 2-hydroxy-6-methoxy-4-methylbenzoate 
• 15346-85-7 Dimethyl 2,4-dihydroxy-6-methylbenzene-1,3-dicarboxylate 
• 771-03-9 3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one 
• 56364-25-1 4-hydroxy-6-methyl-3-[(2E)-3-phenylprop-2-enoyl]-2H-pyran-2-one 
• 1004-36-0 2,6-dimethylpyrone 

Relevant academic research and scientific papers

[4+2] Cycloadditions between 2-pyrones and benzyne. Application to the synthesis of binaphthyls

Cycloaddition of benzyne to 2-pyrones affords the corresponding naphthalene derivatives, the intermediate bicyclic adduct not being detected. Benzopyrones do not react with benzyne under similar conditions probably because this would require the fused aromatic ring to lose aromaticity in the Diels-Alder transition state, which is therefore destabilized. 4-Bromo-2-naphthoic acid methyl ester (obtained by cycloaddition of benzyne to 3-bromo-5-carboxymethylpyran-2-one) can be transformed into 3,3'-dicarboxymethyl-1,1'-binaphthyl by Ni-mediated dimerization.

Reactions of fused and unfused α-pyrones with magnesium alkoxide, sodium alkoxide and water as the nucleophile: effects of chelation

The reactions between a series of α-pyrones (two mono- and three fused) and the non-chelating base sodium alkoxide, the chelating base magnesium alkoxide and water as the nucleophile, have been studied.Aromatic and other products formed reflect the points of attack on the pyrone systems and when sodium methoxide is used the ensuing cyclisation is preferentially by aldol mechanisms.The employment of excess magnesium methoxide or ethoxide gives magnesium-chelated precursors and the nature of products now depends on these intermediates, and the protection afforded by such magnesium chelation to the reaction products.In the case of structures containing chelated β-keto ester features the chelates are screened from attack as aldol acceptors, but are effective Claisen acceptors.In such chelates an adjacent methylene is activated by further magnesium alkoxide to act as an aldol or Claisen donor.These contrasting aldol/Claisen reactivities, as between a non-chelating and a chelating base, are illustrated in the ensuing chemistry of the pyrones.Treatment with water releases the main carbon chain with decarboxylation, from which new products may form.