4862-94-6

Basic information

• Product Name: 4-AMINO-N-(2-HYDROXYETHYL)BENZENESULFONAMIDE
• Synonyms: 4-AMINO-N-(2-HYDROXYETHYL)BENZENESULFONAMIDE;4-[(2-Hydroxyethyl)sulphamoyl]aniline;4-Amino-N-(2-hydroxyethyl)benzenesulphonamide;2-(4-AMINOPHENYLSULFONAMIDO)ETHANOL
• CAS NO: 4862-94-6
• Molecular Formula: C₈H₁₂N₂O₃S
• Molecular Weight: 216.26
• Mol File: 4862-94-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 97 °C
• Boiling Point: 445°C at 760 mmHg
• Flash Point: 222.9°C
• Appearance: /
• Density: 1.383g/cm³
• Vapor Pressure: 1.06E-08mmHg at 25°C
• Refractive Index: 1.602
• CAS DataBase Reference: 4-AMINO-N-(2-HYDROXYETHYL)BENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-N-(2-HYDROXYETHYL)BENZENESULFONAMIDE(4862-94-6)
• EPA Substance Registry System: 4-AMINO-N-(2-HYDROXYETHYL)BENZENESULFONAMIDE(4862-94-6)

Safety Data

• Hazardous Substances Data: 4862-94-6(Hazardous Substances Data)

Usage

General Description

4-AMINO-N-(2-HYDROXYETHYL)BENZENESULFONAMIDE is a chemical compound that belongs to the class of sulfonamides. It has a molecular formula of C8H11N2O3S and a molecular weight of 221.25 g/mol. 4-AMINO-N-(2-HYDROXYETHYL)BENZENESULFONAMIDE is commonly used as a pharmaceutical intermediate in the synthesis of various drugs, including antineoplastic agents and diuretics. It is also known for its antibacterial and antifungal properties, making it a potential candidate for medical applications. The chemical structure of 4-AMINO-N-(2-HYDROXYETHYL)BENZENESULFONAMIDE contains an amino group, a hydroxyl group, and a benzene ring attached to a sulfonamide group, which contribute to its therapeutic potential and functional versatility in various biological contexts.

InChI:InChI=1/C8H12N2O3S/c9-7-1-3-8(4-2-7)14(12,13)10-5-6-11/h1-4,10-11H,5-6,9H2

Upstream product

• 18226-05-6 N-(2-hydroxyethyl)-4-nitrobenzenesulfonamide 
• 20535-76-6 N-acetyl-sulfanilic acid-(2-hydroxy-ethylamide) 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 121-60-8 p-acetylaminobenzenesulfonyl chloride 

Downstream Products

• 945618-71-3 4-(6-amino-4-cyclohexylmethoxypyrimidin-2-ylamino)-N-(2-hydroxyethyl)benzenesulfonamide 
• 79917-54-7 nitro-pyrimidine 
• 959368-84-4 N-sulfanilyl-sulfanilic acid-(2-hydroxy-ethylamide) 
• 857622-22-1 N-(N-acetyl-sulfanilyl)-sulfanilic acid-(2-hydroxy-ethylamide) 

Relevant articles and documents

TGF-beta receptor inhibitor

The invention provides a compound shown as a formula (I) and a pharmaceutical composition thereof. The compound shown as the formula (I) of the present invention is useful as a TGF-beta receptor inhibitor, particularly a TGF beta RI inhibitor, for example, in the prevention or treatment of various TGF beta RI (ALK5) mediated related diseases.

Design, synthesis and biological evaluation of GPR55 agonists

GPR55, a G protein-coupled receptor, is an attractive target to alleviate inflammatory and neuropathic pain and treat osteoporosis and cancer. Identifying a potent and selective ligand will aid to further establish the specific physiological roles and pharmacology of the receptor. Towards this goal, a targeted library of 22 compounds was synthesized in a modular fashion to obtain structure-activity relationship information. The general route consisted of coupling a variety of p-aminophenyl sulfonamides to isothiocyanates to form acylthioureas. For the synthesis of a known naphthyl ethyl alcohol motif, route modification led to a shorter and more efficient process. The 22 analogues were analyzed for their ability to serve as agonists at GPR55 and valuable information for both ends of the molecule was ascertained.

Synthesis and biological activity of N-aryl-2-aminothiazoles: Potent pan inhibitors of cyclin-dependent kinases

N-Aryl aminothiazoles 6-9 were prepared from 2-bromothiazole 5 and found to be CDK inhibitors. In cells they act as potent cytotoxic agents. Selectivity for CDK1, CDK2, and CDK4 was dependent of the nature of the N-aryl group and distinct from the CDK2 se