4862-94-6

Usage

Uses

Used in Pharmaceutical Industry:
4-AMINO-N-(2-HYDROXYETHYL)BENZENESULFONAMIDE serves as a pharmaceutical intermediate for the synthesis of a range of drugs, including antineoplastic agents and diuretics. Its presence in these medications aids in the treatment of various conditions, such as cancer and fluid retention.
Used in Antibacterial Applications:
Leveraging its inherent antibacterial properties, 4-AMINO-N-(2-HYDROXYETHYL)BENZENESULFONAMIDE is utilized in medical applications to combat bacterial infections. Its ability to inhibit bacterial growth makes it a valuable component in the development of new antimicrobial therapies.
Used in Antifungal Applications:
Similarly, 4-AMINO-N-(2-HYDROXYETHYL)BENZENESULFONAMIDE's antifungal characteristics position it as a potential candidate for treating fungal infections. Its inclusion in antifungal medications can help address a variety of fungal-related health issues.

InChI:InChI=1/C8H12N2O3S/c9-7-1-3-8(4-2-7)14(12,13)10-5-6-11/h1-4,10-11H,5-6,9H2

Upstream product

• 18226-05-6 N-(2-hydroxyethyl)-4-nitrobenzenesulfonamide 
• 121-60-8 p-acetylaminobenzenesulfonyl chloride 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 20535-76-6 N-acetyl-sulfanilic acid-(2-hydroxy-ethylamide) 

Downstream Products

• 945618-71-3 4-(6-amino-4-cyclohexylmethoxypyrimidin-2-ylamino)-N-(2-hydroxyethyl)benzenesulfonamide 
• 959368-84-4 N-sulfanilyl-sulfanilic acid-(2-hydroxy-ethylamide) 
• 79917-54-7 nitro-pyrimidine 
• 857622-22-1 N-(N-acetyl-sulfanilyl)-sulfanilic acid-(2-hydroxy-ethylamide) 

Relevant academic research and scientific papers

TGF-beta receptor inhibitor

The invention provides a compound shown as a formula (I) and a pharmaceutical composition thereof. The compound shown as the formula (I) of the present invention is useful as a TGF-beta receptor inhibitor, particularly a TGF beta RI inhibitor, for example, in the prevention or treatment of various TGF beta RI (ALK5) mediated related diseases.

Novel Allosteric Activators for Ferroptosis Regulator Glutathione Peroxidase 4

Glutathione peroxidase 4 (GPX4) is essential for cell membrane repair, inflammation suppression, and ferroptosis inhibition. GPX4 upregulation provides unique drug discovery opportunities for inflammation and ferroptosis-related diseases. However, rationa

Design, synthesis and biological evaluation of GPR55 agonists

GPR55, a G protein-coupled receptor, is an attractive target to alleviate inflammatory and neuropathic pain and treat osteoporosis and cancer. Identifying a potent and selective ligand will aid to further establish the specific physiological roles and pharmacology of the receptor. Towards this goal, a targeted library of 22 compounds was synthesized in a modular fashion to obtain structure-activity relationship information. The general route consisted of coupling a variety of p-aminophenyl sulfonamides to isothiocyanates to form acylthioureas. For the synthesis of a known naphthyl ethyl alcohol motif, route modification led to a shorter and more efficient process. The 22 analogues were analyzed for their ability to serve as agonists at GPR55 and valuable information for both ends of the molecule was ascertained.

CHEMICAL COMPOUNDS-576

The invention relates to chemical compounds of the formula (I): or pharmaceutically or pharmaceutically acceptable salts thereof, which possess B-Raf inhibitory activity and are accordingly useful for their anti-cancer activity and thus in methods of trea

Synthesis and biological activity of N-aryl-2-aminothiazoles: Potent pan inhibitors of cyclin-dependent kinases

N-Aryl aminothiazoles 6-9 were prepared from 2-bromothiazole 5 and found to be CDK inhibitors. In cells they act as potent cytotoxic agents. Selectivity for CDK1, CDK2, and CDK4 was dependent of the nature of the N-aryl group and distinct from the CDK2 se