486408-86-0Relevant academic research and scientific papers
8-Mercaptoguanine-based inhibitors of Mycobacterium tuberculosis dihydroneopterin aldolase: synthesis, in?vitro inhibition and docking studies
Czeczot, Alexia de Matos,Roth, Candida Deves,Ducati, Rodrigo Gay,Pissinate, Kenia,Rambo, Raoní Scheibler,Timmers, Luís Fernando Saraiva Macedo,Abbadi, Bruno Lopes,Macchi, Fernanda Souza,Pestana, Víctor Zajaczkowski,Basso, Luiz Augusto,Machado, Pablo,Bizarro, Cristiano Valim
, p. 847 - 855 (2021/03/29)
The dihydroneopterin aldolase (DHNA, EC 4.1.2.25) activity of FolB protein is required for the conversion of 7,8-dihydroneopterin (DHNP) to 6-hydroxymethyl-7,8-dihydropterin (HP) and glycolaldehyde (GA) in the folate pathway. FolB protein from Mycobacteri
HETEROCYCLIC GTP CYCLOHYDROLASE 1 INHIBITORS FOR THE TREATMENT OF PAIN
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Page/Page column 42-43, (2011/04/19)
The present invention relates to the field of small molecule heterocyclic inhibitors of GTP cyclohydrolase (GCH-I), or a tautomer, prodrug, or pharmaceutically acceptable salt thereof. The invention also features pharmaceutical compositions of the compounds and the medical use of these compounds for the treatment or prevention of pain (e.g., inflammatory pain, nociceptive pain, functional pain, or neuropathic pain).
