486408-88-2Relevant academic research and scientific papers
8-Mercaptoguanine-based inhibitors of Mycobacterium tuberculosis dihydroneopterin aldolase: synthesis, in?vitro inhibition and docking studies
Czeczot, Alexia de Matos,Roth, Candida Deves,Ducati, Rodrigo Gay,Pissinate, Kenia,Rambo, Raoní Scheibler,Timmers, Luís Fernando Saraiva Macedo,Abbadi, Bruno Lopes,Macchi, Fernanda Souza,Pestana, Víctor Zajaczkowski,Basso, Luiz Augusto,Machado, Pablo,Bizarro, Cristiano Valim
, p. 847 - 855 (2021/03/29)
The dihydroneopterin aldolase (DHNA, EC 4.1.2.25) activity of FolB protein is required for the conversion of 7,8-dihydroneopterin (DHNP) to 6-hydroxymethyl-7,8-dihydropterin (HP) and glycolaldehyde (GA) in the folate pathway. FolB protein from Mycobacteri
