486421-65-2

Upstream product

• 486421-47-0 6-(tert-butyldimethylsilanyloxy)-(2S,3,3aR,6S,7,7aR)-hexahydroindole-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 486421-48-1 6-(tert-butyldimethylsilanyloxy)-(2S,3,3aR,6S,7,7aR)-hexahydroindole-2-carboxylic acid methyl ester 
• 171523-45-8 (2S,3aR,6S,7aR)-3a-(benzoyloxy)-6-hydroxy-2,3,3a,6,7,7a-hexahydroindole-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 171523-63-0 <2S-(2β,3aβ,7aβ)>-2,3,3a,6,7,7a-hexahydro-3a-benzoyloxy-6-oxo-1H-indole-1,2-dicarboxylic acid 1-benzyl 2-methyl ester 
• 144534-49-6 (2S,3aR,7aR)-3a-hydroxy-6-oxo-2,3,3a,6,7,7a-hexahydroindole-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 171523-46-9 (2S,3aR,6S,7aR)-6-hydroxy-2,3,3a,6,7,7a-hexahydroindole-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 486421-49-2 6-(tert-butyldimethylsilanyloxy)-1-(3-phenylallyl)-(2S,3,3aR,6S,7,7aR)-hexahydro-1H-indole-2-carboxylic acid methyl ester 
• 486421-50-5 1-(3-phenylallyl)-6-hydroxy-(2S,3,3aR,6S,7,7aR)-hexahydro-1H-indole-2-carboxylic acid methyl ester 

Downstream Products

• 106861-40-9 didehydrotuberostemonine 
• 486421-60-7 8-des-ethyl-(8S)-phenylseleno-(-)-tuberostemonine 
• 6879-01-2 (-)-tuberostemonine 
• 486421-66-3 (2S,7aS,10aS,10bR)-8-Oxo-10-phenylsulfanyl-1,2,4,7,7a,8,9,10,10a,10b-decahydro-azepino[3,2,1-hi]indole-2-carboxylic acid methyl ester 
• 828921-38-6 7-allyl-1-(3-phenylallyl)-6-hydroxy-(2S,3,3aR,6,7,7aR)-hexahydro-1H-indole-2-carboxylic acid methyl ester 
• 828921-54-6 (2S,3aR,4S,7R,7aR)-7-Allyl-4-dimethylcarbamoylmethyl-1-((E)-3-phenyl-allyl)-2,3,3a,4,7,7a-hexahydro-1H-indole-2-carboxylic acid methyl ester 
• 828921-43-3 (5S)-[7-allyl-6-hydroxy-1-(3-phenylallyl)-(2S,3,3aR,6S,7S,7aR)-hexahydro-1H-indol-2-yl]-3-methyldihydrofuran-2-one 
• 828921-56-8 7-allyl-6-(tert-butyldimethylsilanyloxy)-1-(3-phenylallyl)-(2S,3,3aR,6S,7S,7aR)-hexahydro-1H-indole-2-carboxylic acid methyl ester 
• 828921-39-7 7-allyl-4-dimethylcarbamoylmethyl-1-(3-phenylallyl)-(2S,3,3aR,4R,7S,7aR)-hexahydro-1H-indole-2-carboxylic acid methoxymethylamide 
• 828921-41-1 7-allyl-6-(tert-butyldimethylsilanyloxy)-1-(3-phenylallyl)-(2S,3,3aR,6S,7S,7aR)-hexahydro-1H-indole-2-carboxylic acid methoxymethyl amide 
• 828921-44-4 2-[7-allyl-2-((4S)-methyl-5-oxotetrahydrofuran-2-yl)-1-(3-phenylallyl)-(2S,3,3aR,4R,7S,7aR)-hexahydro-1H-indol-4-yl]-N,N-dimethylacetamide 
• 828921-50-2 (-)-8-des-ethyl,(8S)-phenylseleno-13-epituberostemonine 
• 486421-51-6 7-allyl-1-(3-phenylallyl)-6-oxo-(2S,3,3aR,6,7,7aR)-hexahydro-1H-indole-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Asymmetric total syntheses of tuberostemonine, didehydrotuberostemonine, and 13-epituberostemonine

Detailed experimental approaches toward the pentacyclic Stemona alkaloids tuberostemonine and didehydrotuberostemonine and the close analogue 13-epituberostemonine are described. The syntheses originate with a hydroindolinone derivative that can be obtain

Total synthesis of (-)-tuberostemonine

The first total synthesis of the complex pentacyclic Stemona alkaloid tuberostemonine was accomplished in 24 steps and in 1.4% overall yield from a hydroindole intermediate which is readily obtained in three steps from Cbz-L-tyrosine. An innovative synthe