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Relevant academic research and scientific papers

Simple and efficient method for synthesis of bis(indolyl) methanes with Cu(BF4)2sio2 under mild conditions

A simple and efficient synthesis of bis(indolyl) methanes by the reaction of indoles with various carbonyl compounds in the presence of a catalytic amount of cupric fluoroborate [Cu(BF4)2SiO2] afforded the corresponding bis(indolyl) methanes in excellent yields. The remarkable selectivity under mild and neutral conditions and commercially available, inexpensive catalyst are attractive features of this method.

Phosphine-Free Manganese(II)-Catalyst Enables Acceptorless Dehydrogenative Coupling of Alcohols with Indoles

Herein, an air-stable, molecularly defined NNN?Mn(II) pincer complex catalyzed acceptorless dehydrogenative coupling of alcohols with indoles is reported. A wide variety of symmetrical and unsymmetrical bis(indolyl)methane derivatives as well as some structurally important products such as Vibrindole A, Turbomycin B alkaloid, Antileukemic, and Anticancer agents were synthesized. Mechanistic studies illustrate the importance of the NH moiety in the complex and the crucial role of metal-ligand cooperation during catalysis. (Figure presented.).

Thiamine hydrochloride as a recyclable organocatalyst for the synthesis of bis(indolyl)methanes, tris(indolyl)methanes, 3,3-di(indol-3-yl)indolin-2-ones and biscoumarins

Thiamine hydrochloride was identified as an eco-friendly organocatalyst for the synthesis of a broad range of bis(indolyl)methanes in good to excellent yields. Green chemistry matrix calculations showed high atom economy and a small E-factor for the reaction. Moreover, the simple and easy operational protocol using a small amount of thiamine hydrochloride (1 mol%) makes this procedure an alternative approach for this transformation industrially. This protocol was also extended to the synthesis of naturally occurring alkaloids such as tris(indolyl)methane, arundine, vibrindole A, 3,3-di(indol-3-yl)indolin-2-ones and biscoumarin derivatives.

Solventless Mechanosynthesis Of Bis(Indolyl)Methanes

Ball-milling technique as a solvent-free and an alternative green process was investigated for the eco-benign synthesis of bis(indolyl)methanes (BIMs) from various aldehydes and selected ketones with indoles in high yields. The present methodology has sev

A simple and efficient supramolecular chemistry approach for synthesis of bis(indolyl)methanes using aqueous β -cyclodextrin as green promoter host

Background: In the recent years, various bis-heterocyclic compounds are reported for their varied biological activities. Bis(indolyl)methanes and its derivatives are commonly present in over 3000 natural isolates and reported for its broad spectrum of bio

Synthesis and characterization of Polyindole and its catalytic performance study as a heterogeneous catalyst

The catalytic performance study of polyindole as a heterogeneous catalyst is reported for the synthesis of 3,3'-arylmethylene-bis-1H-Indole derivatives using various substituted aldehydes and indole under reflux reaction condition with good to excellent y

Expeditious, mild and solvent free synthesis of Bis(indolyl)methanes, Using a mixture of phosphorus pentoxide in methanesulfonic acid

Highly rapid and efficient synthesis of Bis(indolyl)methanes has been developed by using a mixture of phosphorus pentoxide in Methanesulfonic acid (Eaton's reagent) at ambient temperature under solvent free condition.

Synthesis of bis(indolyl) methanes in catalyst- and solvent-free reaction

Efficient synthesis of bis(indolyl) methanes by the reaction of indoles with various carbonyl compounds in the absence of catalyst and solvent afforded the corresponding bis(indolyl) methanes in excellent yields.

Unique versatility of Amberlyst 15. An acid and solvent-free paradigm towards synthesis of bis(heterocyclyl)methane derivatives

Bis(heterocyclyl)methanes, key intermediates for a variety of chemical, biochemical and material science relevant targets, have been obtained in a synthetically useful manner using Amberlyst 15 ion-exchange resin. This method promises versatility, cost-ef

Tetrabutylammonium tribromide as efficient catalyst in the synthesis of bis(indolyl)methanes

An efficient procedure has been developed for the synthesis of bis(indolyl)methane derivatives by condensation of aldehydes with indole in the presence of tetrabutylammonium tribromide as catalyst.