486445-15-2Relevant academic research and scientific papers
Styrylquinazoline derivatives as HIV-1 integrase inhibitors
Lee, Jae Yeol,Park, Jang Hyun,Lee, Sook Ja,Park, Hokoon,Lee, Yong Sup
, p. 277 - 282 (2002)
Styrylquinazoline derivatives were prepared by Perkin condensation and evaluated for inhibitory activity against HIV-1 integrase. Among them, compound 5 c containing a free catechol ring was the most potent (IC50 = 20.8 ± 1.9 μM) and showed 6-fold more potency than the corresponding styrylquinoline compound (IC50 = 130.7 ± 8.6 μM).
