486445-72-1

Upstream product

• 486445-73-2 2,4-dihydroxy-N-[3-(2-{2-[3-(2,2,2-trifluoro-acetylamino)-propoxy]-ethoxy}-ethoxy)-propyl]-butyramide 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 4246-51-9 4,7,10-trioxa-1,13-diaminotridecane 
• 486445-74-3 4-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-hydroxy-N-[3-(2-{2-[3-(2,2,2-trifluoro-acetylamino)-propoxy]-ethoxy}-ethoxy)-propyl]-butyramide 

Relevant academic research and scientific papers

(R)-2,4-Dihydroxybutyramide seco-Pseudonucleosides: New Versatile Homochiral Synthons for Synthesis of Modified Oligonucleotides

(Matrix Presented) Two series of seco-pseudonucleoside synthons were synthesized from (R)-(+)-α-hydroxy-γ-butyrolactone and (R)-(-)-pantolactone by aminolysis, side-chain protection, dimethoxytritylation, and phosphitylation or solid-phase attachment. The phosphoramidites and solid supports were used in automated DNA synthesis to prepare oligonucleotides modified with one or more 2,4-dihydroxybutyramide units bearing side-chain reporter groups. These new oligonucleotide modification reagents allow the introduction of a label into any desired position within an oligonucleotide chain during solid-phase assembly.