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5-(o-tolylamino)uracil is an organic compound with the molecular formula C10H11N3O2. It is a derivative of uracil, a pyrimidine base found in RNA, and features an o-tolylamine group attached to the 5-position of the uracil ring. This chemical is known for its potential applications in medicinal chemistry, particularly as a building block for the synthesis of various biologically active molecules. The o-tolylamine group introduces a phenyl ring with a methyl substituent in the ortho position, which can significantly influence the chemical's reactivity and interactions with other molecules. The compound's structure and properties make it a valuable intermediate in the development of new drugs and pharmaceuticals.

4870-32-0

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4870-32-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4870-32-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,8,7 and 0 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 4870-32:
(6*4)+(5*8)+(4*7)+(3*0)+(2*3)+(1*2)=100
100 % 10 = 0
So 4870-32-0 is a valid CAS Registry Number.

4870-32-0Relevant academic research and scientific papers

Synthesis of 1-(aryloxyalkyl)-5-(arylamino)uracils

Ozerov,Novikov,Brel',Solodunova

, p. 611 - 616 (2007/10/03)

In an attempt to obtain new non-nucleoside inhibitors of the reverse transcriptase HIV-1, we have carried out the synthesis of 1-(benzyloxymethyl)- and 1-[2-(4-R-phenoxy)ethyl]-5-(arylamino)uracils. Indirect alkylation of trimethylsilyl derivatives of 5-(arylamino)uracils with benzyl chloromethyl ether by the Gilbert-Jones method did not affect the exocyclic amino group and gave the corresponding 1-(benzyloxymethyl) derivatives in 58-74% yield. Alkylation of 5-(arylamino)uracils with 1-bromo-2-(4-R-phenoxy)ethane in anhydrous DMF in the presence of potassium carbonate gave a mixture of N1-mono- and N1,N1-disubstituted products with an overall yield of 46-55%. 1998 Plenum Publishing Corporation.

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