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Upstream product

• 873-83-6 4-Amino-2,6-dihydroxypyrimidine 
• 2826-32-6 3-nitrobenzylidenemalononitrile 
• 99-61-6 3-nitro-benzaldehyde 
• 109-77-3 malononitrile 
• 873-83-6 6-amino-2,4-dihydroxypyrimidine 

Relevant academic research and scientific papers

A clean procedure for synthesis of pyrido[d]pyrimidine derivatives under solvent-free conditions catalyzed by zro2 nanoparticles

A simple one-pot method for the preparation of 7-amino-2,4-dioxo-5-aryl-1, 2,3,4-tetrahydropyrido[2,3- d]pyrimidine-6-carbonitriles 4 from aromatic aldehydes, malononitrile and 4(6)-aminouracil in the presence of ZrO2 nanoparticles (ZrO2 NPs) as an effici

A novel amphipathic low-melting complex salt: An efficient homogeneous catalyst for synthesis of pyran-annulated heterocyclic scaffolds and pyrido[2,3-d]pyrimidines

The reaction of triethyl(sulfonyl)ammonium chlorosulfonate with 1,1,3,3-tetramethylguanidine (TMG) gave a low-melting complex salt with amphipathic and acidic characters. The salt has a great tendency towards solvation of organic substrates upon slight heating, so it was employed as a homogeneous acidic and functional ionic liquid catalyst in the expedient synthesis of benzo[b]pyrans, pyrano[4,3-b]pyrans, pyrano[3,2-c]quinolones, and pyrido[2,3-d]pyrimidines. The catalytic activity of the complex salt is much better than the simple salts composing it. Spectroscopic studies and chemical analysis of the salt revealed that its empirical formula is in agreement with neutralization of TMG by two H2SO4 molecules. The HSO4 ? anions of the salt seem to form extensive H-bonding with the constituting ammonium cations and Cl?, resulting in melting point depression of the complex salt due to the melting points of pure triethylamine and TMG hydrochloride salts. Another significant feature of this solid salt is that it can preserve its composition even after several times of separation from aqueous extracts and can be handled easily without danger.

Electrocatalytic multicomponent assembling of aminouracils, aldehydes and malononitrile: An efficient approach to 7-aminopyrido[2,3-d]pyrimidine-6-carbonitrile derivatives

The electrocatalytic multicomponent transformation of 6-aminouracils, aromatic aldehydes and malononitrile in ethanol in an undivided cell in the presence of potassium bromide as an electrolyte leads to 7-aminopyrido[2,3- -d]pyrimidine-6-carbonitrile deri

Facile synthesis of pyridopyrimidine and coumarin fused pyridine libraries over a Lewis base-surfactant-combined catalyst TEOA in aqueous medium

A highly convergent and efficient protocol, for the facile synthesis of a library of coumarin fused pyridine and pyridopyrimidine derivatives, has been developed by applying a Lewis base-surfactant-combined catalyst (LBSC) triethanolamine (TEOA). The method described has the benefits of operational simplicity and excellent yields of the targeted molecule. The LBSCs were found to form stable colloidal dispersions rapidly in the presence of reaction substrates in water, even when the substrates are solid. In light of the increased demand for reduction of organic solvents in industry, the surfactant aided Lewis base catalysis described here may have immense practical consequences in organic synthesis. This work may not only lead to environmentally benign systems but also will provide a newer aspect of organic chemistry in water.

One-pot synthesis of pyrido[2,3-d]pyrimidines via efficient three-component reaction in aqueous media

(Chemical Equation Presented) A short and facile synthesis of pyrido[2,3-d]pyrimidine derivatives was accomplished in good yields via the three-component reaction of aldehydes, alkyl nitriles and aminopyrimidines in water in the presence of triethylbenzyl

Clean synthesis of pyrido[2,3-d]pyrimidines in aqueous media

The reaction of substituted cinnamonitriles and 4-amino-2,6- dihydroxypyrimidine or 2,4-diamino-6-hydroxypyrimidine in water in the presence of triethylbenzylammonium chloride (TEBA) as catalyst affords a clean synthesis of pyrido[2,3-d]pyrimidine derivat

Pyrido[2,3-d]pyrimidines and pyrimido [5′,4′: 5,6]pyrido[2,3-d] pyrimidines as new antiviral agents: Synthesis and biological activity

A series of 7-amino- and 7-oxo-5-aryl-6-cyanopyrido[2,3-d]pyrimidines, 4 and 11, respectively, and pyrimido[5′,4′:5,6]pyrido[2,3-d]pyrimidine derivatives 6 and 7 was synthesized and investigated as antiviral agents. Different synthetic strategies for the preparation of the target compounds were explored. A synthetic procedure for 4 and 11 starting with 6-amino-1,2,3,4-tetrahydro-2,4-dioxopyrimidine, proper aldehyde, and malononitrile or ethyl cyanoacetate, respectively, in a one-pot reaction proved to be the method of choice for preparation of compounds of such type. Construction of another pyrimidine ring on the pyridine nucleus of compound 4 was achieved either by reaction with phenyl iso(thio)cyanate or with formic acid to yield 6 and 7, respectively. The structure of the prepared compounds was confirmed through elemental analysis and spectral investigation. Most of the newly synthesized compounds were subjected to antiviral activity testing against herpes simplex virus (HSV) where some of them show good activities.