4871-25-4

Basic information

• Product Name: 4-(4-Methoxyphenyl)-2(3H)-thiazolone hydrazone
• Synonyms: 4-(4-methoxyphenyl)-2(3h)-thiazolone hydrazone;2-hydrazino-4-(4-methoxyphenyl)-1,3-thiazole(SALTDATA: HCl);[4-(4-Methoxy-phenyl)-thiazol-2-yl]-hydrazine hydrochloride
• CAS NO: 4871-25-4
• Molecular Formula: C₁₀H₁₁N₃OS
• Molecular Weight: 221.28
• Mol File: 4871-25-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 416.2 °C at 760 mmHg
• Flash Point: 205.5 °C
• Appearance: /
• Density: 1.316 g/cm³
• Vapor Pressure: 3.91E-07mmHg at 25°C
• Refractive Index: 1.666
• PKA: 0.50±0.40(Predicted)
• CAS DataBase Reference: 4-(4-Methoxyphenyl)-2(3H)-thiazolone hydrazone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Methoxyphenyl)-2(3H)-thiazolone hydrazone(4871-25-4)
• EPA Substance Registry System: 4-(4-Methoxyphenyl)-2(3H)-thiazolone hydrazone(4871-25-4)

Safety Data

• Hazardous Substances Data: 4871-25-4(Hazardous Substances Data)

Usage

General Description

4-(4-Methoxyphenyl)-2(3H)-thiazolone hydrazone is a chemical compound with the molecular formula C11H10N2OS. It is a thiazolone derivative with a hydrazone functional group, and its structure consists of a thiazolone ring with a methoxyphenyl group and a hydrazone moiety attached. 4-(4-Methoxyphenyl)-2(3H)-thiazolone hydrazone has been studied for its potential biological activities, including its antimicrobial and antioxidant properties. Additionally, it has been investigated for its potential use in the development of pharmaceuticals and as a building block for the synthesis of other compounds. Overall, 4-(4-Methoxyphenyl)-2(3H)-thiazolone hydrazone is a versatile chemical with potential applications in various fields of science and industry.

InChI:InChI=1/C10H11N3OS/c1-14-8-4-2-7(3-5-8)9-6-15-10(12-9)13-11/h2-6H,11H2,1H3,(H,12,13)

Upstream product

• 79-19-6 thiosemicarbazide 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 1629144-43-9 2-phenoxy-4-(4-methoxyphenyl)thiazole 
• 2196-99-8 2-chloro-1-(4-methoxyphenyl)ethanone 
• 146942-43-0 3,4,5-Trimethoxy-benzoic acid N'-[4-(4-methoxy-phenyl)-thiazol-2-yl]-hydrazide 
• 2104-01-0 2-chloro-4-(4-methoxy-phenyl)-thiazole 
• 4872-77-9 acetic acid N'-[4-(4-methoxy-phenyl)-thiazol-2-yl]-hydrazide 

Downstream Products

• 78559-91-8 1-(4-methoxybenzylidene)-2-(4-(4-methoxyphenyl)thiazol-2-yl)hydrazine 
• 1609240-27-8 1-(4-(4-methoxyphenyl)thiazol-2-yl)-3-methylindeno[1,2-c]pyrazol-4(1H)-one 
• 1609240-39-2 2-(3-ethylindeno[1,2-c]pyrazol-1(4H)-yl)-4-(4-methoxyphenyl)thiazole 
• 1609240-31-4 3-ethyl-1-(4-(4-methoxyphenyl)thiazol-2-yl)indeno[1,2-c]pyrazol-4(1H)-one 
• 1609240-35-8 4-(4'-methoxyphenyl)-2-(3-methylindeno[1,2-c]pyrazol-1(4H)-yl)thiazole 
• 1609240-23-4 2-(1-(2-(4-(4-methoxyphenyl)thiazol-2-yl)hydrazono)propyl)-1H-indene-1,3(2H)-dione 
• 1609240-19-8 2-(1-(2-(4-(4-methoxyphenyl)thiazol-2-yl)hydrazono)ethyl)-1H-indene-1,3(2H)-dione 
• 61323-74-8 7-(4-methoxy-phenyl)-4,5-dihydro-2H-thiazolo[2,3-c][1,2,4]triazepin-3-one 
• 112447-63-9 2-(3,5-Diphenyl-pyrazol-1-yl)-4-(4-methoxy-phenyl)-thiazole 
• 61323-68-0 3-chloro-propionic acid N'-[4-(4-methoxy-phenyl)-thiazol-2-yl]-hydrazide 
• 128433-02-3 4-(4-Methoxy-phenyl)-2-pyrazol-1-yl-thiazole 

Relevant articles and documents

Novel thiazole–pyrazolone hybrids as potent ACE inhibitors and their cardioprotective effect on isoproterenol-induced myocardial infarction

A facile synthesis of a group of novel thiazole–pyrazolone hybrids and their investigation for angiotensin-converting enzyme (ACE) inhibition are reported in this study. These compounds were synthesized using a well-known approach, based on the condensation of ethyl acetoacetate with thiazolylhydrazines, and characterized by various spectroscopic and analytical techniques. The entire set of compounds displayed a moderate-to-excellent inhibitory activity against ACE. In particular, compound 4i was found to be the most potent ACE inhibitor and was further studied for cardioprotective effects against isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Compound 4i improved the cardiac function and prevented cardiac injury induced by ISO in Sprague Dawley rats. The levels of oxidative stress and proinflammatory cytokines were also restored to near normal by 4i as compared with the ISO group. In the Western blot analysis, compound 4i prevented mitochondrial apoptosis after MI by downregulating the expression of cleaved caspase-3 and Bax, with the upregulation of Bcl-2, as compared with the ISO group.

Spectrophotometric and polarographic studies on the kinetics of hydrolysis of N-(6-methyl-5-nitropyridin-2-yl methylidene)-N′-(substituted thiazol-2-yl)hydrazines

The kinetics of the hydrolysis of hydrazpne derived from nitropyridine 2-carboxaldehyde and 2-hydrazino-4-substituted thiazoles la-e in 10% (v/v) DMF-buffer mixture has been investigated by applying two independent and different techniques viz UV-spectrop