4871-25-4

Usage

Uses

Used in Pharmaceutical Development:
4-(4-Methoxyphenyl)-2(3H)-thiazolone hydrazone is used as a pharmaceutical candidate for its potential biological activities, including antimicrobial and antioxidant properties. Its unique structure and functional groups contribute to its therapeutic potential, making it a valuable compound for the development of new drugs.
Used in Antimicrobial Applications:
In the field of microbiology, 4-(4-Methoxyphenyl)-2(3H)-thiazolone hydrazone is used as an antimicrobial agent, leveraging its ability to inhibit the growth of various microorganisms. This property makes it a promising candidate for the development of new antibiotics and antimicrobial agents to combat drug-resistant infections.
Used in Antioxidant Applications:
4-(4-Methoxyphenyl)-2(3H)-thiazolone hydrazone is used as an antioxidant, capitalizing on its potential to neutralize free radicals and protect cells from oxidative damage. This application is particularly relevant in the development of nutraceuticals and cosmeceuticals, where antioxidants play a crucial role in maintaining health and preventing aging-related conditions.
Used in Chemical Synthesis:
In the chemical industry, 4-(4-Methoxyphenyl)-2(3H)-thiazolone hydrazone is used as a building block for the synthesis of other compounds. Its unique structure and functional groups make it a valuable intermediate in the preparation of various organic and pharmaceutical compounds, contributing to the advancement of chemical synthesis and the development of new materials.
Used in Research and Development:
4-(4-Methoxyphenyl)-2(3H)-thiazolone hydrazone is used in research and development for its potential applications in various scientific fields. Its unique properties and structure make it an interesting subject for further investigation, with the potential to uncover new uses and applications in areas such as materials science, nanotechnology, and biotechnology.

InChI:InChI=1/C10H11N3OS/c1-14-8-4-2-7(3-5-8)9-6-15-10(12-9)13-11/h2-6H,11H2,1H3,(H,12,13)

Upstream product

• 2104-01-0 2-chloro-4-(4-methoxy-phenyl)-thiazole 
• 146942-43-0 3,4,5-Trimethoxy-benzoic acid N'-[4-(4-methoxy-phenyl)-thiazol-2-yl]-hydrazide 
• 79-19-6 thiosemicarbazide 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 1629144-43-9 2-phenoxy-4-(4-methoxyphenyl)thiazole 
• 2196-99-8 2-chloro-1-(4-methoxyphenyl)ethanone 
• 4872-77-9 acetic acid N'-[4-(4-methoxy-phenyl)-thiazol-2-yl]-hydrazide 

Downstream Products

• 128433-02-3 4-(4-Methoxy-phenyl)-2-pyrazol-1-yl-thiazole 
• 78559-91-8 1-(4-methoxybenzylidene)-2-(4-(4-methoxyphenyl)thiazol-2-yl)hydrazine 
• 1609240-27-8 1-(4-(4-methoxyphenyl)thiazol-2-yl)-3-methylindeno[1,2-c]pyrazol-4(1H)-one 
• 1609240-39-2 2-(3-ethylindeno[1,2-c]pyrazol-1(4H)-yl)-4-(4-methoxyphenyl)thiazole 
• 1609240-31-4 3-ethyl-1-(4-(4-methoxyphenyl)thiazol-2-yl)indeno[1,2-c]pyrazol-4(1H)-one 
• 1609240-35-8 4-(4'-methoxyphenyl)-2-(3-methylindeno[1,2-c]pyrazol-1(4H)-yl)thiazole 
• 1609240-23-4 2-(1-(2-(4-(4-methoxyphenyl)thiazol-2-yl)hydrazono)propyl)-1H-indene-1,3(2H)-dione 
• 1609240-19-8 2-(1-(2-(4-(4-methoxyphenyl)thiazol-2-yl)hydrazono)ethyl)-1H-indene-1,3(2H)-dione 
• 61323-74-8 7-(4-methoxy-phenyl)-4,5-dihydro-2H-thiazolo[2,3-c][1,2,4]triazepin-3-one 
• 112447-63-9 2-(3,5-Diphenyl-pyrazol-1-yl)-4-(4-methoxy-phenyl)-thiazole 
• 61323-68-0 3-chloro-propionic acid N'-[4-(4-methoxy-phenyl)-thiazol-2-yl]-hydrazide 

Relevant academic research and scientific papers

Novel thiazole–pyrazolone hybrids as potent ACE inhibitors and their cardioprotective effect on isoproterenol-induced myocardial infarction

A facile synthesis of a group of novel thiazole–pyrazolone hybrids and their investigation for angiotensin-converting enzyme (ACE) inhibition are reported in this study. These compounds were synthesized using a well-known approach, based on the condensation of ethyl acetoacetate with thiazolylhydrazines, and characterized by various spectroscopic and analytical techniques. The entire set of compounds displayed a moderate-to-excellent inhibitory activity against ACE. In particular, compound 4i was found to be the most potent ACE inhibitor and was further studied for cardioprotective effects against isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Compound 4i improved the cardiac function and prevented cardiac injury induced by ISO in Sprague Dawley rats. The levels of oxidative stress and proinflammatory cytokines were also restored to near normal by 4i as compared with the ISO group. In the Western blot analysis, compound 4i prevented mitochondrial apoptosis after MI by downregulating the expression of cleaved caspase-3 and Bax, with the upregulation of Bcl-2, as compared with the ISO group.

2,4- and 2,5-disubstituted arylthiazoles: Rapid synthesis by C-H coupling and biological evaluation

Life-threatening infections caused by bacteria that have developed resistance to common antibiotics, such as methicillin-resistant Staphylococcus aureus (MRSA), have become a serious problem in hospitals and other areas all over the world. Thus, the development of an effective class of antibiotics against these bacteria is an urgent subject. Herein, we report a step-economical and diversity-oriented synthesis of a series of 2-arylidenehydrazinyl-4- arylthiazole and 2-arylidenehydrazinyl-5-arylthiazole analogues that utilizes C-H coupling methodologies. A library of 54 new congeners were synthesized and tested for their biological potential. Moreover, new knowledge regarding the structure-activity relationships (SARs) of these heterobiaryl compounds was collected. Copyright

Spectrophotometric and polarographic studies on the kinetics of hydrolysis of N-(6-methyl-5-nitropyridin-2-yl methylidene)-N′-(substituted thiazol-2-yl)hydrazines

The kinetics of the hydrolysis of hydrazpne derived from nitropyridine 2-carboxaldehyde and 2-hydrazino-4-substituted thiazoles la-e in 10% (v/v) DMF-buffer mixture has been investigated by applying two independent and different techniques viz UV-spectrop

MAOI activity of some novel series of substituted thiazol-2-yl-hydrazines

Three series of 2-thiazolylhydrazines were synthetized and evaluated for their MAO inhibitory (MAOI) activity, both by in vivo tests, to assay their influence on several MAOI activity-related parameters (the variation on blood pressure induced by tyramine