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N-tosyl-L-leucine, also known as N-tosyl-L-leucinamide, is a chemical compound with the molecular formula C12H18N2O4S. It is a derivative of L-leucine, an essential amino acid, where the amino group is protected by a tosyl group (tosyl = 4-methylbenzenesulfonyl). N-tosyl-L-leucine is widely used in peptide synthesis as a protected amino acid, allowing for the controlled formation of peptide bonds in the presence of other functional groups. The tosyl group can be removed under mild conditions, making it a valuable tool in the synthesis of complex peptide structures. N-tosyl-L-leucine is also employed in various biochemical and pharmaceutical applications, including the study of enzyme mechanisms and the development of new drugs.

4874-50-4

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4874-50-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4874-50-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,8,7 and 4 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 4874-50:
(6*4)+(5*8)+(4*7)+(3*4)+(2*5)+(1*0)=114
114 % 10 = 4
So 4874-50-4 is a valid CAS Registry Number.

4874-50-4Relevant academic research and scientific papers

A new access to 3,5-disubstituted piperazinones via Pd(0)-catalyzed amination

Ferber, Benoit,Lemaire, Sébastien,Mader, Mary M.,Prestat, Guillaume,Poli, Giovanni

, p. 4213 - 4216 (2007/10/03)

An original synthetic route toward 3,5-disubstituted piperazinones has been developed. The method relies upon a 6-exo intramolecular process between a sulfonylated nitrogen atom of amino acid derivation and an η3-allyl-palladium moiety. This cyclization process generates the two possible (cis and trans) diastereoisomers whose ratio depends on the amino acid employed. The bulkier the amino acid residue, the higher the observed cis:trans ratio. Convincing evidence for reversible intramolecular addition of the nitrogen nucleophile to the η3-allyl-palladium complex is put forward.

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