4875-41-6 Usage
Uses
Used in Pharmaceutical Industry:
4-(4-chlorophenyl)tetrahydroimidazo[4,5-c]pyridine is used as a GABA receptor agonist for its potential therapeutic applications in the treatment of conditions such as anxiety, depression, and epilepsy. Its ability to modulate the GABAergic system, which plays a crucial role in regulating neuronal excitability and inhibiting neurotransmitter release, makes it a promising candidate for the development of new medications targeting these conditions.
Used in Medicinal Chemistry Research:
4-(4-chlorophenyl)tetrahydroimidazo[4,5-c]pyridine is used as a ligand for different receptors and enzymes in the field of medicinal chemistry. Its unique structure and potential pharmacological properties make it an interesting target for the development of new drugs and therapeutic agents. Researchers are exploring its interactions with various biological targets to identify novel applications and optimize its pharmacological profile.
Used in Drug Development:
4-(4-chlorophenyl)tetrahydroimidazo[4,5-c]pyridine is used as a compound of interest in drug development due to its potential pharmaceutical properties and unique structure. Its investigation as a GABA receptor agonist and a ligand for different receptors and enzymes highlights its potential in the development of new medications for various therapeutic areas. 4-(4-chlorophenyl)tetrahydroimidazo[4,5-c]pyridine's pharmacological profile and its interactions with biological targets are being studied to optimize its efficacy, safety, and selectivity in treating specific conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 4875-41-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,8,7 and 5 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 4875-41:
(6*4)+(5*8)+(4*7)+(3*5)+(2*4)+(1*1)=116
116 % 10 = 6
So 4875-41-6 is a valid CAS Registry Number.
InChI:InChI=1/C12H12ClN3/c13-9-3-1-8(2-4-9)11-12-10(5-6-14-11)15-7-16-12/h1-4,7,11,14H,5-6H2,(H,15,16)
4875-41-6Relevant academic research and scientific papers
α-Carbonic anhydrases are strongly activated by spinaceamine derivatives
Akocak, Suleyman,Lolak, Nabih,Bua, Silvia,Nocentini, Alessio,Karakoc, Gulcin,Supuran, Claudiu T.
, p. 800 - 804 (2019/01/25)
A series of 4-substituted-spinaceamine (4,5,6,7-tetrahydro-imidazolo[4,5-c]pyridine) were prepared from histamine and aromatic aldehydes Schiff bases, and investigated as activators of four human (h) carbonic anhydrase (CA, EC 4.2.1.1) isoforms, the cytosolic hCA I, II and VII, and the membrane-associated hCA IV. All isoforms were effectively activated by the new derivatives, and the nature of the moiety in position 4 of the bicyclic system was the factor influencing activation properties against all isoforms. For hCA I, these compounds showed KAs in the range of 2.52–21.5 μM, the most effective activator being 4-(2-hydroxyphenyl)-spinaceamine. For hCA II the activation constants ranged between 0.60 and 17.2 μM, with 4-(2,3,5,6-tetrafluorophenyl)- spinaceamine the best activator. Affinity for hCA IV was in the range of 0.52–63.8 μM, and the same compound as for hCA II was the most effective activator. The most sensitive isoform for activation was the brain-associated hCA VII, for which KAs in the range of 82 nM–4.26 μM were observed. Effective hCA VII activators were the (2-bromophenyl)-, 2,3,5,6-tetrafluorophenyl- and furyl-substituted spineaceamines (KAs of 82–95 nM). As CA activators may have pharmacologic applications in various fields, this work provides interesting derivatives for further studies.
