4878-04-0

Basic information

• Product Name: 2-(4-methoxyphenoxy)-2-methylpropanoyl chloride
• Synonyms: 2-(4-methoxyphenoxy)-2-methylpropanoyl chloride;propanoyl chloride, 2-(4-methoxyphenoxy)-2-methyl-
• CAS NO: 4878-04-0
• Molecular Formula: C₁₁H₁₃ClO₃
• Molecular Weight: 228.67212
• Mol File: 4878-04-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-methoxyphenoxy)-2-methylpropanoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenoxy)-2-methylpropanoyl chloride(4878-04-0)
• EPA Substance Registry System: 2-(4-methoxyphenoxy)-2-methylpropanoyl chloride(4878-04-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 4878-04-0(Hazardous Substances Data)

Usage

Formation

Combination of 4-methoxyphenol and 2-methylpropanoyl chloride The acyl chloride is formed by reacting these two starting materials.

Usage

Organic synthesis reagent It is commonly used in the esterification of carboxylic acids, which is a key step in creating various organic compounds.

Application

Preparation of pharmaceuticals and agrochemicals The compound serves as an important intermediate in the synthesis of drugs and chemicals used in agriculture.

Versatility

Versatile building block for functionalized compounds Due to its ability to undergo numerous chemical reactions, it is a valuable component in creating a wide range of compounds.

Safety

Slightly irritant properties It is important to handle and use 2-(4-methoxyphenoxy)-2-methylpropanoyl chloride with appropriate safety measures to avoid irritation or other adverse effects.

Upstream product

• 17509-54-5 α-(4-methoxyphenoxy)-2-methylpropionic acid 
• 150-76-5 4-methoxy-phenol 

Downstream Products

• 116762-27-7 2-(4-methoxyphenoxy)-2-methyl-propionyl-cyanomethylenetriphenylphosphorane 

Relevant articles and documents

The formation of benzoxacin-3-ones: Via intramolecular Nicholas reactions and synthesis of 8-membered heliannuols

The γ-carbonyl cations generated from propargyl ether-Co2(CO)6 complexes undergo intramolecular Nicholas reactions to give dehydrobenzoxacin-3-one-Co2(CO)6 complexes in good yields. Reductive decomplexation and subsequent manipulation allows the synthesis of (±)-heliannuol K methyl ether and the formal syntheses of (±)-heliannuol K, (±)-heliannuol A, and (-)-heliannuol L.

Pd(II)-catalyzed ortho - Or meta-C-H olefination of phenol derivatives

A combination of weakly coordinating auxiliaries and ligand acceleration allows for the development of both ortho- and meta-selective C-H olefination of phenol derivatives. These reactions demonstrate the feasibility of directing C-H functionalizations when functional groups are distal to target C-H bonds. The meta-C-H functionalization of electron-rich phenol derivatives is unprecedented and orthogonal to previous electrophilic substitution of phenols in terms of regioselectivity. These methods are also applied to functionalize α-phenoxyacetic acids, a fibrate class of drug scaffolds.

TANDEM INTRAMOLECULAR WITTIG AND CLAISEN REARRANGEMENT REACTIONS IN THE THERMOLYSIS OF 2-METHYL-2-PHENOXY-PROPIONYL-CYANOMETHYLENETRIPHENYLPHOSPHORANES: SYNTHESIS OF SUBSTITUTED 2H-1-BENZOPYRANS AND BENZOFURANS

The preparation and thermolysis in vacuum of 2-methyl-2-phenoxy-propionyl-cyanomethylenetriphenylphosphorane and derivatives containing methyl-, methoxy- and chloro- substituents in the phenoxy ring is reported.The method merges the preparation of phenyl