4878-36-8

Usage

Uses

Used in Pharmaceutical Industry:
RARECHEM AL BO 1272 is used as a solvent for various pharmaceutical applications, including the formulation of elixirs, syrups, and liquid medications. Its ability to dissolve a wide range of substances, including drugs, makes it an ideal choice for this purpose. Additionally, glycerol is used as a humectant to prevent the crystallization of drugs and maintain their stability.
Used in Cosmetics and Personal Care Industry:
In the cosmetics and personal care industry, RARECHEM AL BO 1272 is used as a humectant to help retain moisture in skin and hair care products, such as lotions, creams, and shampoos. Its ability to absorb water helps to keep the skin and hair hydrated and maintain their natural moisture balance.
Used in Food and Beverage Industry:
RARECHEM AL BO 1272 is used in the food and beverage industry as a humectant, preservative, and sweetener. It helps to retain moisture in baked goods, confections, and icing, preventing them from becoming too dry or hard. Glycerol is also used in the production of e-liquids for electronic cigarettes, providing a smooth and pleasant vaping experience.
Used in Industrial Applications:
In industrial applications, RARECHEM AL BO 1272 is used as a raw material in the production of various chemicals, such as glycerol esters, polyglycerols, and glycerol ethers. It is also used as a component in the manufacturing of explosives, due to its ability to act as an oxygen carrier.
Used in Research and Development:
RARECHEM AL BO 1272 is used in the study of insulin secretion in relation to amiloride, as well as in the development of β-blockers and diuretics. It is also utilized in the determination of impurities in pharmaceuticals, contributing to the quality control and safety of medications.

InChI:InChI=1/C5H5ClN4O2/c6-2-4(8)10-3(7)1(9-2)5(11)12/h(H,11,12)(H4,7,8,10)

Upstream product

• 2609-46-3 amiloride 
• 1458-01-1 3,5-diamino-6-chloro-pyrazine-2-carboxylic acid methyl ester 

Downstream Products

• 1444121-71-4 C₂₅H₃₇ClN₁₀O₄ 
• 1444121-74-7 4-{4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)guanidino]piperidin-1-ylmethyl}benzoic acid 
• 1444121-82-7 N-[2-(4-{4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)guanidino]piperidin-1-ylmethyl}benzenesulfonylamino)ethyl]acetamide 
• 1444121-89-4 C₂₀H₂₅ClN₈O₄ 
• 1444121-91-8 C₂₃H₃₂ClN₉O₄ 
• 1444122-13-7 C₂₃H₃₁ClN₈O₃ 
• 1444122-20-6 C₁₉H₂₃ClN₈O₄ 
• 1444123-12-9 C₂₀H₂₅ClN₈O₄ 
• 1444124-26-8 C₂₃H₃₁ClN₈O₃ 
• 1583272-57-4 (S)-N-(1-benzyl-piperidin-3-yl)-N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidine 
• 1583272-29-0 1-benzyl-4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidino]-1-methyl-piperidinium chloride 
• 1444121-41-8 C₂₁H₂₇ClN₈O₄ 
• 1432293-74-7 4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidinomethyl]-4-phenethyl-piperidine-1-carboxamidine 
• 1432291-72-9 4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidinomethyl]-4-phenethyl-piperidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

TETRA- AND PENTASUBSTITUTED BENZIMIDAZOLIUM COMPOUNDS USEFUL IN THE TREATMENT OF RESPIRATORY DISEASES

The present invention relates to compounds of formula (I), or the tautomers or pharmacologically acceptable acid addition salts thereof, wherein R1, R2, R3, R4, X, and Z have one of the meanings as defined in the specification, to the use of compounds of formula (I) as a medicament, to pharmaceutical composition comprising at least one com? pound of formula (I), as well as to medicament combinations containing one or more compounds of formula (I).

SUBSTITUTED BENZIMIDAZOLIUM COMPOUNDS USEFUL IN THE TREATMENT OF RESPIRATORY DISEASES

The present invention relates to compounds of formula (I), or the tautomers or pharmacologically acceptable acid addition salts thereof, characterized by a topological polar surface area value (TPSA) of at least 145, wherein R1, R2, R3, R4, X, and Z- have one of the meanings as defined in the specification, to the use of compounds of formula (I) as a medicament, to pharmaceutical composition comprising at least one compound of formula (I), as well as to medicament combinations containing one or more compounds of formula (I).

HETEROCYCLIC COMPOUNDS, MEDICAMENTS CONTAINING THEM, USE AND PROCESSES FOR THE PREPARATION THEREOF

The present invention relates to compounds of general formula (I) and the tautomers and the salts thereof, particularly the pharmaceutically acceptable salts thereof with inorganic or organic acids and bases, which have valuable pharmacological properties, particularly an inhibitory effect on epithelial sodium channels, and the use thereof for the treatment of diseases, particularly diseases of the lungs and airways.

NOVEL TETRA- AND PENTASUBSTITUTED BENZIMIDAZOLIUM COMPOUNDS

The present invention relates to compounds of general formula (I) and the tautomers and the salts thereof, particularly the pharmaceutically acceptable salts thereof with inorganic or organic acids and bases, which have valuable pharmacological properties, particularly an inhibitory effect on epithelial sodium channels, the use thereof for the treatment of diseases, particularly diseases of the lungs and airways.

NOVEL BENZIMIDAZOLIUM COMPOUNDS

The present invention relates to compounds of general formula (I) and the tautomers and the salts thereof, particularly the pharmaceutically acceptable salts thereof with inorganic or organic acids and bases, which have valuable pharmacological properties, particularly an inhibitory effect on epithelial sodium channels, the use thereof for the treatment of diseases, particularly diseases of the lungs and airways.

AMILORIDE-TYPE COMPOUNDS AS INHIBITORS IN EPITHELIAL SODIUM CHANNELS FOR THE TREATMENT OF DISEASES OF THE LUNGS AND AIRWAYS

P01-2935/FF 88/88 -88- ABSTRACT The present invention relates to compounds of general formula (I) R N NNH 2 N O N H NH 2 NH 2 X A' A (I) and the tautomersand the salts thereof, particularly the pharmaceutically acceptable salts thereof with inorganic or organic acids and bases, which have valuable pharmacological properties, particularly an inhibitory effect on epithelial sodium channels, the use thereof for the treatmentof diseases, particularly diseases of the lungs and airways.

NOVEL PYRAZINE AMIDE COMPOUNDS

The present invention relates to compounds of formula 1 or pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, R4, R5, R6 and X? have the meanings as indicated in the specification, to their use as a medicament, to their use in the treatment of a disease selected from among respiratory diseases or complaints and allergic diseases of the airways, to pharmaceutical composition comprising at least one of said compound or a pharmaceutically acceptable salt thereof, as well as to medicament combinations containing one or more of said compounds or a pharmaceutically acceptable salt thereof.

NOVEL 5-SUBSTITUTED BENZIMIDAZOLIUM COMPOUNDS

The present invention relates to compounds of general formula (I) and the tautomers and the salts thereof, particularly the pharmaceutically acceptable salts thereof with inorganic or organic acids and bases, which have valuable pharmacological properties, particularly an inhibitory effect on epithelial sodium channels, the use thereof for the treatment of diseases, particularly diseases of the lungs and airways.

NOVEL PYRAZINE AMIDE COMPOUNDS

The present invention relates to compounds of formula 1 or pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, R6 and X- have one of the meanings as indicated in the specification, to their use as a medicament, to their use in the treatment of a disease selected from among respiratory diseases or complaints and allergic diseases of the airways, to pharmaceutical composition comprising at least one of said compound or a pharmaceutically acceptable salt thereof, as well as to medicament combinations containing one or more of said compounds or a pharmaceutically acceptable salt thereof.

NOVEL TETRA- AND PENTASUBSTITUTED BENZIMIDAZOLIUM COMPOUNDS

The present invention relates to compounds of general formula (I), and the tautomers and the salts thereof, particularly the pharmaceutically acceptable salts thereof with inorganic or organic acids and bases, which have valuable pharmacological properties, particularly an inhibitory effect on epithelial sodium channels, the use thereof for the treatment of diseases, particularly diseases of the lungs and airways.