488091-73-2Relevant academic research and scientific papers
Asymmetric synthesis of trans-disubstituted cyclopropanes using phosphine oxides and phosphine boranes
Clarke, Celia,Foussat, Stephanie,Fox, David J.,Pedersen, Daniel Sejer,Warren, Stuart
supporting information; experimental part, p. 1323 - 1328 (2009/12/04)
The stereocontrolled synthesis of trans-disubstituted cyclopropylketones has been achieved from β-alkyl, γ-benzoyl phosphine oxides via a three-step cascade reaction incorporating an acyl transfer, phosphinoyl transfer and cyclisation to form the cyclopropane. Using Evans' chiral oxazolidinone auxiliary and by masking the phosphine oxide moiety as a phosphine borane we have extended the method to the synthesis of enantiomerically-enriched trans-disubstituted cyclopropyl ketones.
