488099-68-9

Upstream product

• 488099-62-3 (3S,4S,5S,6R)-6-[(3,4-dimethoxybenzyl)oxy]-4-hydroxy-5-methyl-3-[(tert-butyldimethylsilyl)oxy]oct-1-ene 
• 488099-63-4 (2R,3S,4S,5R)-5-[(3,4-dimethoxybenzyl)oxy]-3-methoxy-4-methyl-2-[(tert-butyldimethylsilyl)oxy]heptanal 
• 488099-61-2 (2R,3R)-3-(3,4-Dimethoxy-benzyloxy)-2-methyl-pentanal 
• 94339-79-4 (2S,3R)-2-methylpentane-1,3-diol 
• 30414-53-0 methyl propanoyl acetate 
• 107-07-3 2-chloro-ethanol 
• 488099-60-1 (2S,3R,1'S)-1,3-O-[1'-(3,4-dimethoxyphenyl)methylidene]-2-methylpentane 
• 96016-23-8 (2S,3R)-3-(3,4-Dimethoxy-benzyloxy)-2-methyl-pentan-1-ol 
• 78655-79-5 2(R),3(R) methyl 3-hydroxy-2-methylpentanoate 
• 42558-50-9 methyl (3R)-3-hydroxypentanoate 

Downstream Products

• 488099-66-7 2'-chloroethyl (2R,3S,4S,6R,7R,8E,10S,11R)-11-[(3,4-dimethoxybenzyl)oxy]-7-hydroxy-3-methoxy-5-oxo-2-[(tert-butyldimethylsilyl)oxy]-4,6,8,10-tetramethyldodec-8-enoate 

Relevant academic research and scientific papers

Studies on the Synthesis of Tedanolide. 2. Stereoselective Synthesis of a Protected C(1)-C(12) Fragment

(Matrix Presented) Highly diastereoselective syntheses of diketo esters 6a and 6b are described. These intermediates undergo efficient aldol reactions with protected C(13)-C(21) aldehydes 3 and 23, thereby providing advanced C(1)-C(21) tedanolide seco ester precursors 9a and 9b.