4886-27-5Relevant academic research and scientific papers
Preparation of primary amides from functionalized organozinc halides
Schade, Matthias A.,Manolikakes, Georg,Knochel, Paul
supporting information; experimental part, p. 3648 - 3650 (2010/11/04)
Organozinc halides, which are prepared either by direct zinc insertion or halogen-magnesium exchange and subsequent transmetalation with ZnCl2, react smoothly with commercially available trichloroacetyl isocyanate to give, after hydrolysis, the corresponding primary amides. This method is compatible with a variety of functional groups such as an ester or a cyano group. Also heterocyclic-, alkenyl, and acetylenic zinc reagents are converted to the corresponding primary amides under these conditions.
