488703-61-3

Usage

Uses

Used in Pharmaceutical Development:
(S,S)-2-Carbamoylcyclohexanecarboxylic acid is used as a building block for the synthesis of pharmaceutical drugs due to its unique chiral structure and potential reactivity in chemical reactions.
Used in Chemical Research:
(S,S)-2-Carbamoylcyclohexanecarboxylic acid serves as a valuable compound in chemical research, where its properties and reactivity can be studied to gain insights into the behavior of similar chiral molecules and their potential applications in various fields.
Note: Since the provided materials do not specify any particular industry or application reason for (S,S)-2-Carbamoylcyclohexanecarboxylic acid, the uses listed above are general and based on the information given. Further research and experimentation would be necessary to identify specific applications in different industries.

Upstream product

• 85-42-7 trans-1,2-cyclohexanedicarboxylic anhydride 
• 31982-85-1 (1S,2S)-trans-1,2-cyclohexanedicarboxylic anhydride 

Downstream Products

• 312965-07-4 (S,S)-trans-N-(9-fluorenylmethoxycarbonyl)-2-aminocyclohexanecarboxylic acid 
• 488703-60-2 (1S,2S)-2-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylic acid 
• 158414-45-0 (1S,2S)-(+)-2-aminocyclohexane-1-carboxylic acid hydrochloride 

Relevant academic research and scientific papers

Enantiomerically pure β-amino acids: A convenient access to both enantiomers of trans-2-aminocyclohexanecarboxylic acid

Enantiomerically pure trans-2-aminocyclohexanecarboxylic acid is an important building block for helical β-peptides. We report here that this amino acid can be obtained from trans-cyclohexane-1,2-dicarboxylic acid in good yield by a simple one-pot procedure comprising cyclization to the anhydride, amide formation with ammonia, and a subsequent Hofmann-type degradation with phenyliodine(III) bis(trifluoroacetate) (PIFA) as the oxidant. The N-Fmoc- and N-BOC-protected derivatives were obtained by treatment of the amino acid with Fmoc-OSu and BOC2O, respectively. The N-BOC derivative could be prepared in even better overall yield by a one-pot procedure leading directly from trans-cyclohexane-1,2-dicarboxylic acid to the N-BOC-protected amino acid. Both enantiomers of the starting trans-1,2-cyclohexanedicarboxylic acid can be obtained easily and in large quantities by separating commercially available racemic trans-1,2-cyclohexanedicarboxylic acid using either (R)- or (S)-1-phenethylamine. X-ray crystallography of the diastereomerically pure salt obtained from (R)-1-phenethylamine revealed that the configuration of the diacid component is (1R,2R), and not (1S,2S) as reported in the literature. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.

Thiazolidinone compounds and composition for angina pectoris comprising the compounds as an active ingredient

A thiazolidinone compound represented by general formula (I) or a pharmacoligically acceptable salt thereof, STR1 wherein W represents sulfur or oxygen and X represents --N(R1)--, or alternatively X represents sulfur or oxygen and W represents --N(R1)--, and R1 represents hydrogen, alkyl or substituted alkyl; R2 and R3 are the same or different from each other, and each represents hydrogen, alkyl, substituted alkyl, aryl, or 5- or 6-membered heteroaryl; R4 represents hydrogen, alkyl or substituted C1 -C4 alkyl; R5 represents substituted cycloalkyl which may contain nitrogen, provided the substituents include --B--ONO2 (wherein B represents a single bond or alkylene) as the indispensable member and alkyl groups as optional members; and A represents a single bond or alkylene, has an excellent anti-anginal effect and thus is useful as an angina pectoris remedy or preventive.