488727-99-7

Upstream product

• 95715-87-0 (R)-3-tert-butoxycarbonyl-4-formyl-2,2-dimethyloxazolidine 
• 488727-87-3 ((((1S)-allyl-(2,2,2-trifluoro-acetyl)-amino)-methyl)-2-phenyl-allyl)-carbamic acid tert-butyl ester 
• 488727-83-9 toluene-4-sulfonic acid (2S)-tert-butoxycarbonylamino-3-phenyl-but-3-enyl ester 
• 488727-76-0 2,2-dimethyl-(4S)-(1-phenyl-vinyl)-oxazolidine-3-carboxylic acid tert-butyl ester 
• 488727-73-7 (4R)-benzoyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 488727-71-5 (4R)-(1-hydroxy-phenyl-methyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 488727-79-3 ((1S)-hydroxymethyl-2-phenyl-allyl)-carbamic acid tert-butyl ester 
• 108149-60-6 methyl [(4R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]carboxylate 
• 488727-93-1 1-(2,2,2-trifluoro-acetyl)-(3S)-tert-butoxycarbonyl-amino-4-phenyl-1,2,3,6-tetrahydro-pyridine 

Relevant academic research and scientific papers

Synthesis of trans-(3S)-Amino-(4R)-alkyl- and -(4S)-Aryl-piperidines via Ring-Closing Metathesis Reaction

(Matrix Presented) trans-(3S)-Amino piperidines bearing various alkyl and aryl substituents at the C-4 position were synthesized via a ring-closing metathesis reaction. The absolute stereochemistry was controlled using a protected D-serine as a starting material. Stereoselective hydrogenation of allylamines provided trans-(3S)-amino-(4R)-alkyl- and -(4S)-aryl-piperidines. This procedure presents the first method for the asymmetric synthesis of 4-substituted 3-amino piperidines.