488748-77-2Relevant academic research and scientific papers
Pyrrolidine-5,5-trans-lactams. 1. Synthesis and incorporation into inhibitors of hepatitis C virus NS3/4A protease.
Andrews, David M,Carey, Seb J,Chaignot, Helene,Coomber, Barry A,Gray, Norman M,Hind, S Lucy,Jones, Paul S,Mills, Gail,Robinson,Slater, Martin J
, p. 4475 - 4478 (2007/10/03)
[reaction: see text] In this, the first of two letters, we outline the use of the pyrrolidine-5,5-trans-lactam template to design small, neutral, mechanism-based inhibitors of hepatitis C NS3/4A protease. The hitherto unreported reaction of the acyl imini
