488791-46-4

Upstream product

• 69739-34-0 t-butyldimethylsiyl triflate 
• 488791-44-2 (12Z,16E)-(3S,6R,7S,8S,14R,15S)-15-(tert-Butoxy-diphenyl-silanyloxy)-1,3-bis-(tert-butyl-dimethyl-silanyloxy)-7-hydroxy-4,4,6,8,12,14,16-heptamethyl-17-(2-methyl-thiazol-4-yl)-heptadeca-12,16-dien-5-one 
• 488791-38-4 (S)-4-Benzyl-3-[(6E,10E)-(2S,8R,9S)-9-(tert-butoxy-diphenyl-silanyloxy)-6-chloromethyl-2,8,10-trimethyl-11-(2-methyl-thiazol-4-yl)-undeca-6,10-dienoyl]-oxazolidin-2-one 
• 470462-89-6 (3S,4S)-4-hydroxy-3,5-dimethyl-6-(2-methylthiazol-4-yl)-1,5-hexadiene 
• 488791-35-1 4-[(E)-(3S,4S)-3-(tert-Butoxy-diphenyl-silanyloxy)-2,4-dimethyl-hexa-1,5-dienyl]-2-methyl-thiazole 
• 488791-30-6 (E)-(2R,3S)-3-(tert-Butoxy-diphenyl-silanyloxy)-2,4-dimethyl-5-(2-methyl-thiazol-4-yl)-pent-4-enal 
• 184246-38-6 (E)-2-methyl-3-(2-methylthiazol-4-yl)acrylaldehyde 
• 17922-24-6 tert-butyloxydiphenylsilyl chloride 
• 488791-40-8 (6Z,10E)-(2S,8R,9S)-9-(tert-Butoxy-diphenyl-silanyloxy)-2,6,8,10-tetramethyl-11-(2-methyl-thiazol-4-yl)-undeca-6,10-dien-1-ol 
• 488791-42-0 (6Z,10E)-(2S,8R,9S)-9-(tert-Butoxy-diphenyl-silanyloxy)-2,6,8,10-tetramethyl-11-(2-methyl-thiazol-4-yl)-undeca-6,10-dienal 
• 355009-17-5 3,5-bis-(tert-butyl-dimethyl-silanyloxy)-2,2-dimethyl-pentanoic acid phenyl ester 
• 355009-03-9 5-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-2,2-dimethyl-pentanoic acid phenyl ester 
• 187527-25-9 (-)-(5S)-5,7-bis{[tert-butyl(dimethyl)silyl]oxy}-4,4-dimethylheptan-3-one 
• 89922-82-7 3-(tert-butyldimethylsilanyloxy)propionaldehyde 

Downstream Products

• 488791-48-6 (12Z,16E)-(3S,6R,7S,8S,14R,15S)-15-(tert-Butoxy-diphenyl-silanyloxy)-3,7-bis-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-4,4,6,8,12,14,16-heptamethyl-17-(2-methyl-thiazol-4-yl)-heptadeca-12,16-dien-5-one 

Relevant academic research and scientific papers

Conformation-activity relationships in polyketide natural products. Towards the biologically active conformation of epothilone

The conformation-activity relationships for the biologically active polyketide, epothilone, have been determined. Computer-based molecular modeling and high field NMR techniques have provided the solution preferences for epothilones 1 and 2. For the C1-C8

Conformation-activity relationships in polyketide natural products: A new perspective on the rational design of epothilone analogues

The syntheses of C14-methyl analogues of epothilone B and D are described. Conformational analysis using computational methods, X-ray crystallography, and NMR studies showed that the stereochemistry at C14 has a pronounced effect on the conformation of th