489-53-2Relevant articles and documents
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Hollis et al.
, p. 100,101,103 (1961)
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TASTE MODIFYING COMPOUND
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Page/Page column 10-11, (2013/02/28)
The present invention relates to the use of Formula (I) where Y represents * denoting the point at which the moiety bonds to the bicyclic ring, in any one of its stereoisomenc forms or mixtures thereof to confer, enhance, impart and/or modify the tingling sensation.
Side-chain bromination of osthol using N-bromosuccinimide and some related reactions
Krishnaswamy, N. R.,Vijayan, K. K.
, p. 664 - 666 (2007/10/02)
Osthol when treated with N-bromosuccinimide under free radical conditions gives 8-(3-bromomethyl-2-butenyl)-7-methoxycoumarin (2), whereas under ionic conditions the product obtained is 8-(2-bromo-3-hydroxy-3-methylbutyl)-7-methoxycoumarin (5) which on reaction with sodium borohydride affords osthol epoxide (7) (meranzin).The epoxide 7 is converted back into the bromohydrin 5 by the action of HBr in dioxane and to 8-(2-amino-3-hydroxy-3-methylbutyl)-7-methoxycoumarin (8) by the action of ammonia.