489395-99-5Relevant academic research and scientific papers
An epiisopicropodophyllin aza analogue via palladium-catalyzed pseudo-domino cyclization
Poli, Giovanni,Giambastiani, Giuliano
, p. 9456 - 9459 (2007/10/03)
A new aza analogue of epiisopicropodophyllin (the C-3 epimer of podophyllotoxin) has been synthesized exploiting two original strategic steps. Rings A/B and E are entered at an early stage via a cationic benzhydrylation process. A palladium-catalyzed pseudo-domino (Pd-PDOM) intramolecular process generates rings C/D in a single synthetic operation.
