489462-19-3Relevant academic research and scientific papers
Facile one-pot synthesis of N-alkylated benzimidazole and benzotriazole from carbonyl compounds
Meng, Xu,Li, Xiaolong,Chen, Wenlin,Zhang, Yuanqing,Wang, Wen,Chen, Jinying,Song, Jinli,Feng, Huijie,Chen, Baohua
, p. 349 - 356 (2014/04/17)
An efficient one-pot N-alkylation of benzimidazole and benzotriazole from carbonyl compounds and tosylhydrazide has been accomplished via copper powder-catalyzed N - H bond insertion affording N-alkylated products in good yields. The reaction can tolerate a wide range of carbonyl compounds, such as aryl, alkyl, heterocyclic and α,β-unsaturated ketones, and aldehydes.
Intramolecular arylation of benzimidazoles via Pd(II)/Cu(I) catalyzed cross-dehydrogenative coupling
Pereira, Kyle C.,Porter, Ashley L.,Deboef, Brenton
supporting information, p. 1729 - 1732 (2014/03/21)
Electron poor benzimidazole substrates were arylated via an intramolecular cross-dehydrogenative coupling (CDC) reaction. These CDC reactions were catalyzed by a Pd(II)/Cu(I) catalyst system, capable of producing moderate yields on a large library of substrates. The substrate scope consisted of tethered arene-benzimidazoles that upon coupling, produced a fused polycyclic motif.
Synthesis of 1-substituted benzimidazoles from o-bromophenyl isocyanide and amines
Lygin, Alexander V.,De Meijere, Armin
experimental part, p. 5138 - 5141 (2010/01/03)
o-Bromophenyl isocyanide (1-Br) reacts with various primary amines under Cu1 catalysis to afford 1 -substituted benzimidazoles 4 in moderate to good yields (38-70%, 13 examples). Analogously, 2-b:romo-3-isocyanothiophene (6) furnishes-substituted 3H-thieno[2,3-d]imidazoles 7 (44-49%, 3 examples).
