489464-20-2

Upstream product

• 53157-64-5 Z-Pro-NHNHBoc 
• 489464-16-6 3-{benzyloxy-[1-({2-[2-(N'-tert-butoxycarbonyl-hydrazinocarbonyl)-pyrrolidin-1-yl]-1-methyl-2-oxo-ethyl}-methyl-carbamoyl)-ethyl]-carbamoyl}-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester 
• 489464-15-5 N'-[1-(2-methylamino-propionyl)-pyrrolidine-2-carbonyl]-hydrazinecarboxylic acid tert-butyl ester 
• 64851-33-8 H-Pro-NHNH-Boc 
• 870-46-2 t-butoxycarbonylhydrazine 
• 489464-18-8 (R)-3-{Benzyloxy-[(S)-1-({(R)-2-[(S)-2-(N'-tert-butoxycarbonyl-hydrazinocarbonyl)-pyrrolidin-1-yl]-1-methyl-2-oxo-ethyl}-methyl-carbamoyl)-ethyl]-carbamoyl}-tetrahydro-pyridazine-1-carboxylic acid benzyl ester 
• 489464-13-3 N'-(1-{2-[(9H-fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-pyrrolidine-2-carbonyl)-hydrazinecarboxylic acid tert-butyl ester 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 

Downstream Products

• 489464-30-4 (1R,4S,7R,13S,16R,19S,20S)-3-Benzyloxy-20-benzyloxycarbonylamino-16-((S)-1-benzyloxy-ethyl)-19-isopropyl-4,6,7-trimethyl-2,5,8,14,17,21-hexaoxo-18-oxa-3,6,9,15,22,23-hexaaza-tricyclo[20.4.0.0^9,13]hexacosane-23-carboxylic acid benzyl ester 
• 489464-24-6 3-benzyloxy-16-(1-benzyloxy-ethyl)-19-isopropyl-4,6,7-trimethyl-2,5,8,14,17,21-hexaoxo-20-(2,2,2-trichloro-ethoxycarbonylamino)-18-oxa-3,6,9,15,22,23-hexaaza-tricyclo[20.4.0.0^9,13]hexacosane-23-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Synthesis of an L-proline modified mimetic of the A83586C antitumour cyclodepsipeptide

A mimetic of the A83586C cyclodepsipeptide has been synthesised via a three-segment coupling protocol involving dipeptides 9, 8 and 7; in contrast to our previous synthesis of A83586C, where the HATU-mediated macrolactamisation proceeded in 25% yield, the