4905-17-3

Basic information

• Product Name: N-benzyl-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide
• Synonyms: 2H-isoindole-2-acetamide, 1,3-dihydro-1,3-dioxo-N-(phenylmethyl)-
• CAS NO: 4905-17-3
• Molecular Formula: C₁₇H₁₄N₂O₃
• Molecular Weight: 294.3047
• Mol File: 4905-17-3.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 545.6°C at 760 mmHg
• Flash Point: 283.8°C
• Density: 1.317g/cm³
• Vapor Pressure: 5.83E-12mmHg at 25°C
• Refractive Index: 1.632
• CAS DataBase Reference: N-benzyl-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide(4905-17-3)
• EPA Substance Registry System: N-benzyl-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide(4905-17-3)

Safety Data

• Hazardous Substances Data: 4905-17-3(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 292067-82-4 N^α-phthaloyl glycine acid fluoroide 
• 33357-94-7 N-Phthaloyl-glycin-p-methoxybenzylester 
• 85-44-9 phthalic anhydride 
• 4702-13-0 N-phthaloylglycine 
• 6780-38-7 N-phthaloylglycine chloride 
• 83539-71-3 N-phthaloylglycine-2-phenyliminooxazolidine 
• 6780-48-9 N-phthaloylglycine anhydride 
• 2945-03-1 N-benzyl-2-bromoacetamide 
• 1074-82-4 potassium phtalimide 
• 78425-85-1 (N,N-phthaloyl-glycyl)-phosphoric acid dibenzyl ester 

Downstream Products

• 109564-16-1 N-(1-benzyl-1H-tetrazol-5-ylmethyl)-phthalimide 
• 39796-52-6 N-benzyl-2-aminoacetamide 

Relevant articles and documents

Radical-Mediated Activation of Esters with a Copper/Selectfluor System: Synthesis of Bulky Amides and Peptides

Herein, we describe a new approach for the activation of esters via a radical-mediated process enabled by a copper/Selectfluor system. A variety of para-methoxybenzyl esters derived from bulky carboxylic acids and amino acids can be easily converted into the corresponding acyl fluorides, directly used in the one-pot synthesis of amides and peptides. As a proof of concept, this method was applied to the iterative formation of sterically hindered amide bonds.

Synthesis and screening of cyclooxygenase inhibitory activity of some 1,3-dioxoisoindoline derivatives

In this study, 15 compounds bearing N,Nphthaloylacetamide structure designed by the molecular simplification approach based on thalidomide structure were synthesized and evaluated for inhibitory potencies against cyclooxgenase (COX) isoenzymes, namely COX-1 and COX-2. The results suggested that the N,Nphthaloylacetamide structure, as a primary amide, has inhibitory activity against cyclooxygenase isoenzymes with a higher COX-1 selectivity. The conversion of the primary amide to secondary or tertiary derivatives lowered the potency but favored the COX-2 selectivity thus yielding the compounds with stronger COX-2 inhibiting activity. ECV · Editio Cantor Verlag.

NOVEL 2-AMINO-QUINAZOLINE DERIVATIVES USEFUL AS INHIBITORS OF β-SECRETASE (BACE)

The present invention is directed to novel 2-amino-3, 4-dihydro-quinazoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of P-secretase, also known as n-site cleaving enzyme and BACE.