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Relevant academic research and scientific papers

Alternative Procedures for the Macrolactamisation of ω-Azido Acids

ω-Azido acids, after activation of the carboxyl groups as mixed anhydrides, N3(CH2)nCOOCOAr (Ar = 3,5-dinitrophenyl or 2,4,6-trichlorophenyl), can be converted to macrolactams in good yields by treatment with Bu3P under high-dilution conditions; the prese

The invention of radical reactions. Part XXV. A convenient method for the synthesis of the acyl derivatives of N-hydroxypyridine-2-thione

Treatment of the readily available di-N-oxide - of 2-thiopyridine disulfide 6 with tributylphosphine in the presence of a carboxylic acid provides a convenient and high yielding synthesis of the acyl derivatives 2 of N-hydroxy-2-thio-pyridone. Application of this procedure to the acids 17 and 18 gave, after irradiation in the presence of t-butylthill, the desired decarboxylated derivatives in high (>90%) yield.

Activation of Dithiocarbamate by 2-Halothiazolium Salts

Activation of dithiocarbamate salts with 2-halo-3-alkyl-4-phenylthiazolium salt and subsequent one-pot nucleophilic reaction with N, S, and O nucleophiles provided substituted thioureas, dithiocarbamates, and thiocarbamates or amides, respectively, under very mild conditions.A useful thiocarbonyl-transfer reaction is also described that consists of activation of imidazolodithiocarbamate and a subsequent one-pot nucleophilic reaction. (Thiocarbonyl)diimidazole is generated in situ.

Additives Based on Liquid Crystal Forming Structure Elements for Suppressing Racemization in Peptide Synthesis by the DCC- and Mixed Anhydrides Methods

A new type of additives suppressing racemization during peptide synthesis by the DCC- and mixed anhydrides methods are liquid crystal forming organic molecules or similar compounds with a specific long chain structure.The suppressing effect of the new additives was followed by the Anderson test, the modifid Young and n.m.r. tests.There was no racemization in a new Leu-enkephalin synthesis by the mixed anhydrides method with azoxybenzene as additive.

SYNTHESIS OF MESOIONIC TRIAZOLOPYRIDINE. III. APPLICATIONS OF N-ACYL MESOIONIC TRIAZOLOPYRIDINES AS ACYLATING REAGENTS.

Utility of N-acyl mesoionic triazolopyridines as acylating reagents was investigated concerning with peptide synthesis. Several dipeptides and N-alkoxycarbonyl amino acids were prepared by use of these reagents.