491600-94-3 Usage
Uses
Celastramycin A is a bioactive compound isolated from endophytic bacteria.
Biological Activity
celastramycin a is an antibiotic that inhibits the growth of bacteria and mycobacteria and is also a potent innate immune suppressor [1][2].celastramycin a is a benzoyl pyrrole-type compound isolated from endophytic bacteria streptomyces mab-quh-8 living in plants of the celastraceae family. celastramycin a exhibited high activity against a series of multiresistent bacteria and mycobacteria [1]. celastramycin a inhibited the growth of gram-positive bacteria and mycobacteria with minimal inhibitory concentration (mic) as low as 0.05 μg/ml [1]. in the ex vivo drosophila culture system, celastramycin a showed a potent immunosuppressive effect with ic50 value of 0.008 μg/ml. in human umbilical vein endothelial cells (huvecs), celastramycin a potently inhibited the production of il-8 with ic50 value of 0.06 μg/ml. so celastramycin a could be used as a lead compound for novel immunosuppressive agents [2].
references
[1]. pullen c, schmitz p, meurer k, et al. new and bioactive compounds from streptomyces strains residing in the wood of celastraceae. planta. 2002 nov;216(1):162-7.[2]. kikuchi h, sekiya m, katou y, et al. revised structure and synthesis of celastramycin a, a potent innate immune suppressor. org lett. 2009 apr 16;11(8):1693-5.
Check Digit Verification of cas no
The CAS Registry Mumber 491600-94-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,9,1,6,0 and 0 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 491600-94:
(8*4)+(7*9)+(6*1)+(5*6)+(4*0)+(3*0)+(2*9)+(1*4)=153
153 % 10 = 3
So 491600-94-3 is a valid CAS Registry Number.
491600-94-3Relevant academic research and scientific papers
Revised structure and synthesis of celastramycin A, A potent innate immune suppressor
Kikuchi, Haruhisa,Sekiya, Mizuki,Katou, Yasuhiro,Ueda, Kazunori,Kabeya, Takahiro,Kurata, Shoichiro,Oshima, Oshiteru
supporting information; experimental part, p. 1693 - 1695 (2009/10/02)
After searching for natural substances that regulate Innate Immunity using the ex vivo Drosophila culture system, a benzoyl pyrrole-type compound, celastramycin A, was Identified and Isolated as a potent suppressor. By synthesizing the previously reported
