491610-75-4

Upstream product

• 913494-94-7 2-(2,4-di(benzyloxy)phenyl)acetaldehyde 
• 13246-46-3 2,4-dibenzyloxybenzaldehyde 
• 5631-68-5 3-(2,4-Dihydroxyphenyl)propionic Acid 
• 491610-74-3 benzyl 3-(2,4-dibenzyloxyphenyl)propionate 

Downstream Products

• 491610-76-5 3-(2,4-dibenzyloxyphenyl)propyl p-tosylate 
• 491610-79-8 1,11-bis(2,4-dibenzyloxy-5-formylphenyl)-4,8-dioxaundecane 
• 491610-78-7 1,11-bis(2,4-dibenzyloxyphenyl)-4,8-dioxaundecane 
• 491610-81-2 1,11-bis(5-cyano-2,4-dihydroxyphenyl)-4,8-dioxaundecane 
• 491610-77-6 1-(3-bromopropyl)-2,4-dibenzyloxybenzene 
• 115692-62-1 1-Allyl-2,4-bis-benzyloxy-benzene 

Relevant academic research and scientific papers

RESORCINOL DERIVATIVE AND TYROSINASE ACTIVITY INHIBITOR CONTAINING THE SAME

PROBLEM TO BE SOLVED: To provide a compound showing high tyrosinase inhibitory activity. SOLUTION: The present invention provides resorcinol derivatives represented by formula I and II and a tyrosinase activity inhibitor containing one of them, where n is

Resorcinol alkyl glucosides as potent tyrosinase inhibitors

Resorcinol alkyl glucosides 7–12 were developed as novel tyrosinase inhibitors based on the structure of rhododendrin. These were synthesized from 2,4-dibenzyloxybenzaldehyde using either the Wittig or the Horner-Wadsworth-Emmons reaction with Koenigs-Knorr glycosylation as key steps. The tyrosinase inhibitory activity of 7–12 increased with the length of the alkyl spacer between resorcinol and glucose. The 50% inhibitory concentration (IC50) of tetradecyl derivative 12 was 0.39 μM, making it the most potent of the compounds synthesized. The IC50 of 8 (3.62 μM) with a propyl spacer was ca 10 times that of 7 (35.9 μM) with an ethyl spacer. This significant activity difference suggests that an interaction between resorcinol alkyl glucoside and tyrosinase may increase remarkably if the length of the alkyl spacer exceeds C3.

Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin

Free radicals and reactive oxygen species have the potential to damage a wide variety of organic molecules, typically by oxidizing certain moieties. These damaging species can, for example, be produced by an organism as a by-product of cellular respiratio

Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin

Free radicals and reactive oxygen species have the potential to damage a wide variety of organic molecules, typically by oxidizing certain moieties. The present invention includes methods of using aryl-substituted heterocyclic compounds as antioxidants, a

Desferrithiocin analogue based hexacoordinate iron(III) chelators

Traditional thinking has been that hexacoordinate Fe(III) ligands are more effective at preventing iron's interactions with reactive oxygen species, most particularly the Fe(II)-mediated reduction of hydrogen peroxide to the hydroxyl radical (i.e., Fenton