4918-96-1

Upstream product

• 120-80-9 benzene-1,2-diol 

Downstream Products

• 74282-80-7 2-Hydroxyphenyl N-<<(2,3',6-Trihydroxy-4'-methoxydihydrochalcon-4-yl)oxy>eth-2-yl>sulfamate 
• 866559-93-5 N-ethyl-2-hydroxyl-benzenesulfonamide 
• 291509-88-1 1-[4-amino-3,5-dibromo-N-(2-hydroxyphenoxysulfonyl)-D-phenylalanyl]-4-(1-methyl-4-piperidinyl)piperazine 
• 686344-15-0 C₂₉H₂₈FN₃O₄S 
• 93000-26-1 catecholyl 19-O-(3-sulfo-3-kaliosulfopropyl)steviolbioside 

Relevant academic research and scientific papers

Aryl sulfotransferase from Haliangium ochraceum: A versatile tool for the sulfation of small molecules

Sulfation is an important molecular modification that regulates essential cellular processes and is also implicated in numerous pathological processes. The enzymes responsible for this reaction in living organisms are sulfotransferases. The gene Hoch-5094 from Haliangium ochraceum is annotated as a putative sulfotransferase. The arylsulfotransferase codified by this gene (HocAST) was expressed heterologously in E. coli and showed aryl sulfotransferase activity. Circular dichroism analysis of HocAST showed a main α/β secondary structure that agrees with the overall structure of other cytosolic sulfotransferases. Interestingly, HocAST was able to use both p-nitrophenyl sulfate and 3'-phosphoadenosine-5'-phosphosulfate (PAPS) as sulfuryl donors contrary to that of aryl sulfate sulfotransferase, which cannot use PAPS as a donor. Regarding the specificity towards the acceptor, HocAST has shown quite a wide scope and was able to accept several mono- and dihydroxylated phenols and other phosphorylated compounds as substrates. Sulfation variations: We prove experimentally that the gene Hoch-5094 from Haliangium ochraceum encodes for an aryl sulfotransferase. The codified enzyme, HocAST, may be a very versatile biocatalyst as it is able to use both p- nitrophenyl sulfate (p-NPS) and 3'-phosphoadenosine-5′-phosphosulfate (PAPS) as donors and transfer the sulfuryl group to several phenolic compounds and biologically relevant phosphorylated molecules. GTP(S)=Guanosine-5′- triphosphate(-5′-sulfate), BiPhOH= 4,4'-Biphenol, BiPhOS=4,4'-Biphenol 4-sulfate.

N-Sulfonyl amine-mediated sulfamation of amines

Primary amines are selectively sulfamated by the two-step process of: A. Contacting the amine in liquid phase at low to moderate temperatures with catechol sulfate thereby forming a catechol sulfate addition product, and B. Hydrolyzing the catecho