491831-48-2

Upstream product

• 491831-46-0 bis(1,1-dimethylethyl) [[4-[3-oxo-3-[(4S)-2-oxo-4-phenyl-3-oxazolidinyl]propyl]phenyl]methyl]phosphonate 
• 350038-44-7 3-[(2E)-3-(4-{[bis(tert-butoxy)phosphono]methyl}phenyl)prop-2-enoyl]-(4S)-4-phenyl-1,3-oxazolidin-2-one 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 491831-47-1 3-[4-(di-tert-butoxy-phosphorylmethyl)-benzyl]-4-oxo-4-(2-oxo-4-phenyl-oxazolidin-3-yl)-butyric acid tert-butyl ester 

Downstream Products

• 849606-98-0 N-(1-{2-carbamoyl-1-[2-(7-nitro-benzo[1,2,5]oxadiazol-4-ylamino)-ethylcarbamoyl]-ethylcarbamoyl}-cyclohexyl)-3-[4-(di-tert-butoxy-phosphorylmethyl)-benzyl]-succinamic acid tert-butyl ester 
• 847934-52-5 N-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-2-[4-(diethoxy-phosphoryl)-phenyl]-1-methyl-ethyl}-3-[4-(di-tert-butoxy-phosphorylmethyl)-benzyl]-succinamic acid tert-butyl ester 
• 847934-53-6 N-[2-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-6-(diethoxy-phosphoryl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-3-[4-(di-tert-butoxy-phosphorylmethyl)-benzyl]-succinamic acid tert-butyl ester 
• 936633-54-4 N-{2-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-6-phenethyl-1,2,3,4-tetrahydro-naphthalen-2-yl}-3-[4-(di-tert-butoxy-phosphorylmethyl)-benzyl]-succinamic acid tert-butyl ester 
• 936633-20-4 4-{2-tert-butoxycarbonylmethyl-3-[4-(di-tert-butoxy-phosphorylmethyl)-phenyl]-propionylamino}-4-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-piperidine-1-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Development of a phosphatase-stable phosphotyrosyl mimetic suitably protected for the synthesis of high-affinity Grb2 SH2 domain-binding ligands

Synthesis of (2R)-2-carboxymethyl-3-(4-(phosphonomethyl)phenyl) proprionic acid (5) in tert-butyl-protected form (6) and its use for the preparation of a Grb2 SH2 domain-directed tripeptide (8a) is reported. In extracellular ELISA-based assays, 8a exhibit